Cannabinoid inhibition of rat luteal cell progesterone synthesis.
@article{Burstein1979CannabinoidIO, title={Cannabinoid inhibition of rat luteal cell progesterone synthesis.}, author={Sumner H Burstein and Sheila A. Hunter and T. Scott Shoupe}, journal={Research communications in chemical pathology and pharmacology}, year={1979}, volume={24 2}, pages={ 413-6 } }
Progesterone production by isolated rat luteal cells was inhibited by exposure to various cannabinoids in concentrations from 3.0--16.0 microM. The available evidence points to the cleavage of cholesterol esters as the site of inhibition.
22 Citations
In vitro effects of cannabinoids on follicular function in the rat.
- Biology, MedicineBiology of reproduction
- 1982
It appears that the inhibitory action of cannabinoids is exerted beyond LH binding and activation of adenylate cyclase and prior to pregnenolone formation in the gonadal steroidogenic pathway.
Regulation of gonadotropin-releasing hormone secretion by cannabinoids.
- BiologyEndocrinology
- 2005
This network of immortalized hypothalamic GnRH neurons could serve as a novel mechanism for regulating GnRH secretion where reproductive functions as diverse as the onset of puberty, timing of ovulation, duration of lactational infertility, and initiation/persistence of menopause may be affected.
Cannabinoids Impair the Formation of Cholesteryl Ester in Cultured Human Cells
- Biology, MedicineArteriosclerosis
- 1981
It is concluded that the cannabinoids “compartmentalize” cholesterol and, thus, make it unavailable for regulating cellular cholesterol metabolism, which may occur as a result of enhanced sterol efflux.
Effects of abused substances on male reproductive development
- Medicine, Biology
- 1985
Alcohol, opiates, barbiturates and marijuana have been reported to suppress gonadal function, impair spermatogenesis and decrease sexual activity in men.
Thein vivo effects of tetrahydrocannabinol on the activity of lactate and succinate dehydrogenases in rat preovulatory follicles
- BiologyThe Histochemical Journal
- 2005
A dosage and regimen sufficient to cause significant decreases in the activities of steroidogenic enzymes had little effect on succinate and lactate dehydrogenases in rat preovulatory follicles.
The effects of marijuana extract and delta 9-tetrahydrocannabinol on luteal function in the rhesus monkey.
- Biology, MedicineFertility and sterility
- 1983
Cannabinoids, Reproduction, and Sexual Behavior
- Biology
- 2006
The endocannabinoid system may possess the very realistic possibility of being a relevant system for the development of drugs that may help to treat erectile dysfunction, sexual arousal and desire disorders, and fertility in both men and women.
Cannabinoid-induced hormone changes in monkeys and rats.
- Biology, MedicineJournal of toxicology and environmental health
- 1980
Hormone imbalance may explain cannabinoid-induced embryotoxicity and impaired gonadal function in rats and monkeys exposed to marihuana smoke or pure cannabinoids.
Marihuana: much ado about THC.
- BiologyComparative biochemistry and physiology. C, Comparative pharmacology and toxicology
- 1985
Effects of tetrahydrocannabinol on rat preovulatory follicles: a quantitative cytochemical analysis
- BiologyThe Histochemical Journal
- 2005
Only the enzymes specifically associated with follicular steroidogenesis were affected by administration of the drug, tetrahydrocannabinol.