• Corpus ID: 31147964

Cannabinoid inhibition of rat luteal cell progesterone synthesis.

@article{Burstein1979CannabinoidIO,
  title={Cannabinoid inhibition of rat luteal cell progesterone synthesis.},
  author={Sumner H Burstein and Sheila A. Hunter and T. Scott Shoupe},
  journal={Research communications in chemical pathology and pharmacology},
  year={1979},
  volume={24 2},
  pages={
          413-6
        }
}
Progesterone production by isolated rat luteal cells was inhibited by exposure to various cannabinoids in concentrations from 3.0--16.0 microM. The available evidence points to the cleavage of cholesterol esters as the site of inhibition. 

In vitro effects of cannabinoids on follicular function in the rat.

It appears that the inhibitory action of cannabinoids is exerted beyond LH binding and activation of adenylate cyclase and prior to pregnenolone formation in the gonadal steroidogenic pathway.

Regulation of gonadotropin-releasing hormone secretion by cannabinoids.

This network of immortalized hypothalamic GnRH neurons could serve as a novel mechanism for regulating GnRH secretion where reproductive functions as diverse as the onset of puberty, timing of ovulation, duration of lactational infertility, and initiation/persistence of menopause may be affected.

Cannabinoids Impair the Formation of Cholesteryl Ester in Cultured Human Cells

It is concluded that the cannabinoids “compartmentalize” cholesterol and, thus, make it unavailable for regulating cellular cholesterol metabolism, which may occur as a result of enhanced sterol efflux.

Effects of abused substances on male reproductive development

Alcohol, opiates, barbiturates and marijuana have been reported to suppress gonadal function, impair spermatogenesis and decrease sexual activity in men.

Thein vivo effects of tetrahydrocannabinol on the activity of lactate and succinate dehydrogenases in rat preovulatory follicles

A dosage and regimen sufficient to cause significant decreases in the activities of steroidogenic enzymes had little effect on succinate and lactate dehydrogenases in rat preovulatory follicles.

Cannabinoids, Reproduction, and Sexual Behavior

The endocannabinoid system may possess the very realistic possibility of being a relevant system for the development of drugs that may help to treat erectile dysfunction, sexual arousal and desire disorders, and fertility in both men and women.

Cannabinoid-induced hormone changes in monkeys and rats.

Hormone imbalance may explain cannabinoid-induced embryotoxicity and impaired gonadal function in rats and monkeys exposed to marihuana smoke or pure cannabinoids.

Marihuana: much ado about THC.

  • A. Schurr
  • Biology
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
  • 1985

Effects of tetrahydrocannabinol on rat preovulatory follicles: a quantitative cytochemical analysis

Only the enzymes specifically associated with follicular steroidogenesis were affected by administration of the drug, tetrahydrocannabinol.