Cannabinoid-induced presynaptic inhibition at the primary afferent trigeminal synapse of juvenile rat brainstem slices.

@article{Liang2004CannabinoidinducedPI,
  title={Cannabinoid-induced presynaptic inhibition at the primary afferent trigeminal synapse of juvenile rat brainstem slices.},
  author={Y Liang and C C Huang and Kuei-sen Hsu and Tomoyuki Takahashi},
  journal={The Journal of physiology},
  year={2004},
  volume={555 Pt 1},
  pages={85-96}
}
Systemic or intraventricular administration of cannabinoids causes analgesic effects, but relatively little is known for their cellular mechanism. Using brainstem slices with the mandibular nerve attached, we examined the effect of cannabinoids on glutamatergic transmission in superficial trigeminal caudal nucleus of juvenile rats. The exogenous cannabinoid receptor agonist WIN 55,212-2 (WIN), as well as the endogenous agonist anandamide, hyperpolarized trigeminal caudal neurones and depressed… CONTINUE READING

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