Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.

@article{Jrai1999CannabinoidinducedMV,
  title={Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.},
  author={Zolt{\'a}n J{\'a}rai and Jens A. Wagner and K{\'a}roly Varga and K D Lake and David R. Compton and Billy R. Martin and Anne M. Zimmer and Tom I. Bonner and Nancy E. Buckley and Esteban Mezey and Raj K. Razdan and George Kunos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 24},
  pages={14136-41}
}
Cannabinoids, including the endogenous ligand arachidonyl ethanolamide (anandamide), elicit not only neurobehavioral but also cardiovascular effects. Two cannabinoid receptors, CB1 and CB2, have been cloned, and studies with the selective CB1 receptor antagonist SR141716A have implicated peripherally located CB1 receptors in the hypotensive action of cannabinoids. In rat mesenteric arteries, anandamide-induced vasodilation is inhibited by SR141716A, but other potent CB1 receptor agonists, such… CONTINUE READING
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