Cannabinoid-induced delayed gastric emptying is selectively increased upon intermittent administration in the rat: role of CB1 receptors.

@article{Abalo2011CannabinoidinducedDG,
  title={Cannabinoid-induced delayed gastric emptying is selectively increased upon intermittent administration in the rat: role of CB1 receptors.},
  author={R Abalo and Pablo Antonio Cabezos and G. Gruartmoner de Vera and Visitaci{\'o}n L{\'o}pez-Miranda and Esperanza Herrad{\'o}n and Ma Isabel Mart{\'i}n-Fontelles},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2011},
  volume={23 5},
  pages={457-67, e177}
}
BACKGROUND Cannabinoids acutely administered depress central, cardiovascular and gastrointestinal functions. These effects might be modified upon repeated administration. Compared to the effects induced by daily administration, those induced by intermittent administration are less known. The effect of intermittent treatment with the CB1/CB2 cannabinoid agonist WIN55,212-2 (WIN) was studied in the rat. METHODS Male rats received saline, vehicle or WIN at 0.5 (low-WIN) or 5 (high-WIN) mg kg(-1… CONTINUE READING