Cannabinoid hyperemesis syndrome: an important differential diagnosis of persistent unexplained vomiting

@article{Ruffle2015CannabinoidHS,
  title={Cannabinoid hyperemesis syndrome: an important differential diagnosis of persistent unexplained vomiting},
  author={James K Ruffle and Sanjin Bajgoric and Kiran Samra and Subashini Chandrapalan and Qasim Aziz and Adam D. Farmer},
  journal={European Journal of Gastroenterology \& Hepatology},
  year={2015},
  volume={27},
  pages={1403–1408}
}
Introduction Chronic nausea and vomiting have a detrimental impact on quality of life. When standard diagnostic investigations fail to provide a definitive diagnosis, patients are often attributed as having a functional gastrointestinal disorder such as cyclic vomiting syndrome. Cannabinoid hyperemesis syndrome (CHS) is a relatively recently described entity presenting with symptoms similar to cyclic vomiting syndrome. Methods We carried out a retrospective cohort study of all patients… 
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The experience of treating patients with amitriptyline is reported, and proposed pathophysiologies include neuroendocrine dysfunction, mutations in mitochondrial DNA and re-intoxication effects from cannabis stored in fat tissues are proposed.
Cannabinoid hyperemesis syndrome presentation to the emergency department: A two-year multicentre retrospective chart review in a major urban area.
TLDR
This study suggests that Cannabinoid hyperemesis syndrome (CHS) may be an overlooked diagnosis for nausea and vomiting, a factor that can possibly contribute to unnecessary investigations and treatment in the ED.
Cannabis hyperemesis syndrome: an update on the pathophysiology and management
TLDR
The role of the ECS, its management, and the identification of gaps in the current knowledge of CHS are elaborate to further enhance its understanding in the future.
An overview of the clinical management of cyclic vomiting syndrome in childhood
Abstract This narrative review provides an update on cyclic vomiting syndrome pathogenesis, diagnosis and management, based upon studies published after the 2008 North American Society for Pediatric
Cannabinoid Hyperemesis
Cannabinoid hyperemesis syndrome (CHS) is a paradoxical condition in which a long-term cannabis user suffers an episode of intractable vomiting that may last days separated by longer asymptomatic
Role of chronic cannabis use: Cyclic vomiting syndrome vs cannabinoid hyperemesis syndrome
  • T. Venkatesan, D. Levinthal, W. Hasler
  • Medicine, Psychology
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2019
TLDR
The role of cannabis in the regulation of nausea and vomiting, specifically focusing on both CVS and CHS, is discussed, in order to address controversies in this context and identify limitations in the existing diagnostic framework.
Cannabinoid hyperemesis syndrome and the onset of a manic episode
TLDR
It is suggested that a 3-week period of vomiting in the context of this syndrome contributed to the precipitation of a manic episode by lowering mood stabiliser serum levels, and that this syndrome will have significant consequences for the patient's mental health.
Emerging Role of Aprepitant in Cannabis Hyperemesis Syndrome
TLDR
A case study is reported where aprepitant (Emend) was successfully used as an anti-emetic in the treatment of CHS when all other commonAnti-emetics failed.
[Beneficial Effect of Medical Cannabis in the Treatment of a Pharmacoresistant Nausea Associated with a Somatoform Disorder in a Patient with Post-Polio Syndrome].
TLDR
Cannabis is a treatment option for treatment-resistant symptoms as part of a post-polio syndrome and under the therapy there was a relief of the nausea symptoms and decreased pain.
Gastric Electrical Stimulation Is an Option for Patients with Refractory Cyclic Vomiting Syndrome
TLDR
In a small group of drug-refractory CVS patients, treatments with temporary and permanent GES significantly reduced the severity of gastrointestinal symptoms and frequency of hospital admissions.
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