Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis

@inproceedings{Lowin2015CannabinoidbasedDT,
  title={Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis},
  author={Torsten Lowin and Rainer H Straub},
  booktitle={Arthritis research & therapy},
  year={2015}
}
Chronic inflammation in rheumatoid arthritis (RA) is accompanied by activation of the sympathetic nervous system, which can support the immune system to perpetuate inflammation. Several animal models of arthritis already demonstrated a profound influence of adrenergic signaling on the course of RA. Peripheral norepinephrine release from sympathetic terminals is controlled by cannabinoid receptor type 1 (CB1), which is activated by two major endocannabinoids (ECs), arachidonylethanolamine… CONTINUE READING
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