Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Δ9-tetrahydrocannabinol in C57BL/6J mice

@article{McMahon2007CannabinoidAD,
  title={Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Δ9-tetrahydrocannabinol in C57BL/6J mice},
  author={Lance R. McMahon and Brett C. Ginsburg and Richard J Lamb},
  journal={Psychopharmacology},
  year={2007},
  volume={198},
  pages={487-495}
}
A variety of behavioral procedures have been developed to assess cannabinoid activity in mice; however, the feasibility of establishing Δ9-THC as a discriminative stimulus in mice has not been documented. One goal was to establish Δ9-THC as a discriminative stimulus in mice; after having done so, another goal was to examine the in vivo mechanism of action of Δ9-THC with other cannabinoids and noncannabinoids. C57BL/6J mice (n = 8) were trained to discriminate Δ9-THC (10 mg/kg i.p.) from vehicle… CONTINUE READING

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Differences in the relative potency of SR 141716A and AM 251 as antagonists of various in vivo effects of cannabinoid agonists in C57BL/6J mice

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