Cannabinoid administration increases 5HT1A receptor binding and mRNA expression in the hippocampus of adult but not adolescent rats

@article{Zavitsanou2010CannabinoidAI,
  title={Cannabinoid administration increases 5HT1A receptor binding and mRNA expression in the hippocampus of adult but not adolescent rats},
  author={Katerina Zavitsanou and Hong Wang and Victoria S. Dalton and Vu H. Nguyen},
  journal={Neuroscience},
  year={2010},
  volume={169},
  pages={315-324}
}
Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT1A Receptor Binding in the Hippocampus: Testing the “Two Hit” Hypothesis for the Development of Schizophrenia
TLDR
A synergistic effect of prenatal infection and adolescent cannabinoid exposure on the integrity of the serotoninergic system in the hippocampus that may provide the neurochemical substrate for abnormal hippocampal-related functions relevant to schizophrenia is suggested.
Comparison of Cannabinoid CB 1 Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography
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This ontogenetic pattern, suggesting increase of CB1R during the transition from adolescence to adulthood, is the opposite of most other neuroreceptor systems undergoing pruning during this period.
Comparison of Cannabinoid CB1 Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [18F]MK-9470
TLDR
This ontogenetic pattern, suggesting increase of CB1R during the transition from adolescence to adulthood, is the opposite of most other neuroreceptor systems undergoing pruning during this period.
The bidirectional effect of prelimbic 5-hydroxytryptamine type-4 (5-HT4) receptors on ACPA-mediated aversive memory impairment in adult male Sprague-Dawley rats
TLDR
It is revealed that activation or deactivation of the 5-HT4 receptors in the PL may mediate the IA memory impairment induced by ACPA indicating a modulatory role for the 5 -HT4 serotonergic receptors.
Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats
TLDR
CBD can potentiate the psychoactive and physiological effects of THC in rats, most likely by delaying the metabolism and elimination of THC through an action on the CYP450 enzymes that metabolise both drugs.
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The pattern of CB1 receptor downregulation was similar to that observed in adults treated with cannabinoids in previous studies; however, its magnitude was smaller in adolescents, which may contribute to some acute behavioral effects, the pharmacological cross‐tolerance and the long‐lasting, adverse psychological consequences of cannabinoid exposure during adolescence.
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In vitro autoradiography was used to examine changes in cannabinoid CB1 receptors (targeted with [3H] CP55,940) in rats treated with the potent cannabinoid agonist HU210 suggesting that downregulation ofCB1 receptors may contribute to the induction of tolerance to body weight loss induced by H U210.
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