Cannabinoid Receptors and Their Endogenous Agonist, Anandamide

  title={Cannabinoid Receptors and Their Endogenous Agonist, Anandamide},
  author={Julius Axelrod and Christian C. Felder},
  journal={Neurochemical Research},
Cannabinoids are a class of compound found in marijuana which have been known for their therapeutic and psychoactive properties for at least 4000 years. Isolation of the active principle in marijuana, Δ9-THC, provided the lead structure in the development of highly potent congeners which were used to probe for the mechanism of marijuana action. Cannabinoids were shown to bind to selective binding sites in brain tissue thereby regulating second messenger formation. Such studies led to the… CONTINUE READING


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