Cannabinoid Receptor Localization in Brain: Relationship to Motor and Reward Systems

@article{Herkenham1992CannabinoidRL,
  title={Cannabinoid Receptor Localization in Brain: Relationship to Motor and Reward Systems},
  author={Miles Herkenham},
  journal={Annals of the New York Academy of Sciences},
  year={1992},
  volume={654}
}
  • M. Herkenham
  • Published 1 June 1992
  • Biology
  • Annals of the New York Academy of Sciences
Marijuana (Omnabri satipa) is one of the oldest and most widely used drugs in the world, with a history of use dating back over 4,000 years.l.2 It was not until about twenty years ago that the principal psychoactive ingredient of the marijuana plant was isolated and found to be A9-tetrahydrocannabinol (A9-THC).3-5 A9-THC and other natural and synthetic cannabinoids produce characteristic behavioral and cognitive effect^,^.^ most of which can be attributed to actions on the central nervous… 

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The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a
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