Cannabinoid Receptor 1 trafficking and the role of the intracellular pool: implications for therapeutics.

@article{Grimsey2010CannabinoidR1,
  title={Cannabinoid Receptor 1 trafficking and the role of the intracellular pool: implications for therapeutics.},
  author={Natasha L Grimsey and E. Scott Graham and Mike Dragunow and Michelle Glass},
  journal={Biochemical pharmacology},
  year={2010},
  volume={80 7},
  pages={
          1050-62
        }
}
Cannabinoid Receptor 1 (CB(1)), an abundant G-protein coupled receptor in the CNS, is currently of significant interest as a therapeutic target. Although the cellular control of receptor trafficking is intimately linked with drug effects, CB(1) trafficking is poorly defined in the current literature and conflicting evidence exists as to whether CB(1) should be classified as a recycling, degrading or "dual-fate" receptor. Of particular interest is the widely noted intracellular pool which has… CONTINUE READING
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