Cannabinoid Receptor 1 Mediates Homing of Bone Marrow‐Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury

@article{Wang2017CannabinoidR1,
  title={Cannabinoid Receptor 1 Mediates Homing of Bone Marrow‐Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury},
  author={Lin Wang and Le Yang and Lei Tian and Ping Mai and Shuangshuang Jia and Lin Yang and Liying Li},
  journal={Journal of Cellular Physiology},
  year={2017},
  volume={232}
}
Cannabinoid receptors (CBs) have been implicated in the pathogenesis of various liver diseases, including liver fibrosis. Our previous studies have demonstrated that after liver injury, mouse bone marrow‐derived mesenchymal stem cells (BMSCs) can migrate to the injured liver and differentiate to myofibroblasts, contributing to hepatic fibrogenesis. However, the role of CBs in the homing of BMSCs in liver injury is yet unclear. In this study, we found that both CB1 and CB2 were expressed in… 
View on Wiley
ncbi.nlm.nih.gov
11 Citations
Background Citations
2
Methods Citations
1
Results Citations
1

11 Citations

Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets.

Neurological Regulation of the Bone Marrow Niche.

A comprehensive overview is given of their role and interactions with important cells in the hematopoietic niche, including HSPCs and MSCs, and their effect on HSPC maintenance, regulation and mobilization.

Therapeutic Potential of Exosomes in Pulmonary Fibrosis

Exosomes may become a new direction in the study of drugs for the treatment of pulmonary fibrosis because they are key factors regulating the differentiation of bone marrow mesenchymal stem cells (BMSCs) into myofibroblasts.

Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice

A cell-autonomous role for CB1 receptors in modulating oligodendrogenesis in vivo is supported, which may have a profound impact on the scientific knowledge and therapeutic manipulation of CNS myelination by cannabinoids.

The Critical Role of Cell Homing in Cytotherapeutics and Regenerative Medicine

The authors discuss the important role of cell homing following i) the delivery of ex vivo‐manipulated cellular materials, ii) the transplantation of bone marrow in a bone marrow transplant procedure, and iii) endogenous cell mobilization/recruitment in response to injury and disease.

Bushen Jianpi Quyu Formula Alleviates Myelosuppression of an Immune-Mediated Aplastic Anemia Mouse Model via Inhibiting Expression of the PI3K/AKT/NF-κB Signaling Pathway

The therapeutic effects of BSJPQYF in AA could alleviate myelosuppression through inhibiting the expression of the PI3K/AKT/NF-κB signaling pathway and reduce the protein expression of cleaved caspase-3.

CB1 enhanced the osteo/dentinogenic differentiation ability of periodontal ligament stem cells via p38 MAPK and JNK in an inflammatory environment

The role and mechanism of CB1 is revealed in the osteo/dentinogenic differentiation of periodontal ligament stem cells (PDLSCs) in an inflammatory environment.

The role and mechanism of mitochondrial functions and energy metabolism in the function regulation of the mesenchymal stem cells

This review discusses the research status and current understanding of the role and mechanism of mitochondria, the main organelles responsible for energy metabolism and adenosine triphosphate production in cells, on MSC functions.

Long noncoding RNA Linc00339 promotes triple‐negative breast cancer progression through miR‐377‐3p/HOXC6 signaling pathway

The results illuminated that the novel Linc00339/miR‐377‐3p/HOXC6 axis played a critical role in TNBC progression and might be a promising therapeutic target for TNBC treatment.

Neutrophil Chemotaxis and NETosis in Murine Chronic Liver Injury via Cannabinoid Receptor 1/Gαi/o/ROS/p38 MAPK Signaling Pathway

Neutrophils play an essential role in the control of inflammatory diseases. However, whether cannabinoid receptors (CBs) play a role in neutrophil chemotaxis and NETosis in sterile liver inflammation…

References

SHOWING 1-10 OF 42 REFERENCES

Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis.

Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration

The results suggest that CB2 agonists display potent hepatoprotective properties, in addition to their antifibrogenic effects, and that incubation of hepatic myofibroblasts with JWH‐133 increased tumor necrosis factor‐α and IL‐6 and decreased MMP‐2 expressions.

Increase of mesenchymal stem cell migration by cannabidiol via activation of p42/44 MAPK.

CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis

The study shows that CB1 receptor antagonists hold promise for the treatment of liver fibrosis, and suggests that endocannabinoids may drive both CB2-mediated antifibrogenic effects andCB2-independent profibrogenics effects.

Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis.

It is demonstrated that the cannabinoid receptor CB1 is crucial for leukocyte infiltration and secondary fibroblast activation and that inactivation of CB1 exerts potent antifibrotic effects in inflammation-driven models of fibrosis.

Recruitment of endogenous bone marrow mesenchymal stem cells towards injured liver

Evidence is provided that mBM‐MSCs could be mobilized into the circulation and recruited into the liver after stimulation of liver injury and CCR9, CXCR4 and c‐MET were essential for directing cellular migration towards the injured liver.

Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression.

It is reported for the first time that CB2R signaling affects DC migration in vitro and in vivo, primarily through the inhibition of matrix metalloproteinase 9 (MMP-9) expression.

Effect of erythropoietin on the migration of bone marrow-derived mesenchymal stem cells to the acute kidney injury microenvironment.

Sphingosine 1‐Phosphate Receptors Negatively Regulate Collagen Type I/III Expression in Human Bone Marrow‐derived Mesenchymal Stem Cell

It is found that treatment of hMSCs with TGF‐β1 up‐regulated collagen expression in a dose‐ and time‐dependent manner, and inhibition of S1PR2 by siRNA had no effects on the expression of collagen, and a new regulation mechanism for collagen expression was provided.

Bone marrow-derived mesenchymal stem cells differentiate to hepatic myofibroblasts by transforming growth factor-β1 via sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis.