Cannabinoid Receptor 1 Mediates Homing of Bone Marrow‐Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury

  title={Cannabinoid Receptor 1 Mediates Homing of Bone Marrow‐Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury},
  author={L. Wang and Le Yang and Lei Tian and Ping Mai and Shuangshuang Jia and L. Yang and L. Li},
  journal={Journal of Cellular Physiology},
  • L. Wang, Le Yang, +4 authors L. Li
  • Published 2017
  • Chemistry, Medicine
  • Journal of Cellular Physiology
Cannabinoid receptors (CBs) have been implicated in the pathogenesis of various liver diseases, including liver fibrosis. Our previous studies have demonstrated that after liver injury, mouse bone marrow‐derived mesenchymal stem cells (BMSCs) can migrate to the injured liver and differentiate to myofibroblasts, contributing to hepatic fibrogenesis. However, the role of CBs in the homing of BMSCs in liver injury is yet unclear. In this study, we found that both CB1 and CB2 were expressed in… Expand
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