Cannabinoid Hyperemesis Syndrome: Reports of Fatal Cases

@article{Nourbakhsh2019CannabinoidHS,
  title={Cannabinoid Hyperemesis Syndrome: Reports of Fatal Cases},
  author={Mahra Nourbakhsh and Angela Miller and Jeffery Gofton and G.R.D. Jones and Bamidele A Adeagbo},
  journal={Journal of Forensic Sciences},
  year={2019},
  volume={64}
}
Cannabinoid hyperemesis syndrome (CHS) is one of the more clinically challenging effects of cannabis consumption. It is characterized by cyclic attacks of nausea and vomiting in chronic cannabinoid users and learned behavior of compulsive hot bathing. The deaths of a 27‐year‐old female, a 27‐year‐old male, and a 31‐year‐old male with a history of CHS are reported. The decedents had a history of cyclical nausea and vomiting, chronic cannabinoid use and negative laboratory, radiological and… Expand
[Cannabinoid hyperemesis as a differential diagnosis of nausea and vomiting in the emergency department].
TLDR
The case of a young man in whom the diagnosis was made after four presentations due to the typical anamnesis of cannabinoid hyperemesis syndrome is described, where the symptoms completely receded 6 months after presentation by maintaining cannabis abstinence. Expand
Cannabinoid hyperemesis syndrome in the pregnant patient: clinical case and literature review
TLDR
Cannabinoid hyperemesis syndrome should be considered in the differential diagnosis of vomiting in pregnancy and consumption of cannabis must be systematically included in the anamnesis. Expand
Cannabinoid Hyperemesis
Cannabinoid hyperemesis syndrome (CHS) is a paradoxical condition in which a long-term cannabis user suffers an episode of intractable vomiting that may last days separated by longer asymptomaticExpand
Treatment of Cannabinoid Hyperemesis With Olanzapine: A Case Series
TLDR
Outcomes of the cases reported here suggest that off-label use of olanzapine may be effective in the symptomatic treatment of refractory CHS and may be the preferred treatment in cases in which comorbid psychotic symptoms or agitation are present. Expand
Cannabinoid Hyperemesis Syndrome Survey and Genomic Investigation.
TLDR
This is the largest patient cohort of CHS examined to date, and first to note associated mutations in genes affecting neurotransmitters, the endocannabinoid system, and the cytochrome P450 complex associated with cannabinoid metabolism. Expand
Cannabinoid hyperemesis syndrome
TLDR
Cannabinoid hyperemesis syndrome was first described in 20041 and associates cyclic nausea and vomiting with abdominal pain in regular cannabis users (defined, in the most comprehensive systematic review on CHS, as at least weekly cannabis use). Expand
Cannabinoids in Gastrointestinal Disorders
TLDR
This chapter looks at the pathophysiology and current treatment regimens for CHS, as well as the financial and physical impacts of this unfortunate condition due to long-term cannabis use. Expand
Endocannabinoid system and cannabis hyperemesis syndrome: a narrative update.
TLDR
The putative mechanism of cannabis hyperemesis syndrome is described, with an overview of the clinical features in these patients, and a narrative update on the current evidence on CHS pathophysiology, diagnosis, treatment, and identifying research gaps. Expand
Cannabis Hyperemesis Syndrome in Palliative Care: A Case Study and Narrative Review.
  • I. Howard
  • Medicine
  • Journal of palliative medicine
  • 2019
TLDR
The presentation of cannabis hyperemesis may be atypical in palliative care patients due to disability and more work is needed to improve risk stratification for patients using cannabis for palliatives care. Expand
Cannabis-related emergencies in children and teens.
TLDR
The spectrum of emergency department presentations associated with cannabis use or misuse that are currently seen in the pediatric population are examined, finding a range of symptoms in young children that include hyperkinesis and coma are possible from acute use or exposure. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 38 REFERENCES
Cannabinoid Hyperemesis Syndrome as the Underlying Cause of Intractable Nausea and Vomiting
TLDR
A case of a 30-year-old man who presented to the emergency department with diffuse abdominal pain, nausea, and intractable vomiting, and reported symptomatic relief with prolonged hot showers, which led to the diagnosis of cannabinoid hyperemesis syndrome. Expand
Cannabinoid hyperemesis: a case series.
TLDR
Cannabinoid hyperemesis should be considered in the differential diagnosis of patients presenting with similar symptoms, with the relatively high prevalence of cannabinoid use in the United States and increasing interest in the applications of marijuana for therapeutic purposes. Expand
Cannabinoid Hyperemesis Syndrome Associated With Compulsive Showering and Acute Kidney Injury.
TLDR
It is found that the description of pain can be varied, as opposed to the traditional description of “colicky pain,” and the bathing behavior specifically helps to distinguish cannabinoid hyperemesis syndrome from cyclic vomiting syndrome. Expand
Cannabinoid hyperemesis syndrome: clinical diagnosis of an underrecognised manifestation of chronic cannabis abuse.
TLDR
In the setting of chronic cannabis abuse, patients presenting with chronic severe nausea and vomiting that can sometimes be accompanied by abdominal pain and compulsive hot bathing behaviour, in the absence of other obvious causes, a diagnosis of cannabinoid hyperemesis syndrome should be considered. Expand
Cannabinoid hyperemesis acute renal failure: a common sequela of cannabinoid hyperemesis syndrome.
TLDR
The unique combination of intractable vomiting and constant hot showers seems to put CHS patients at significant risk of severe dehydration and prerenal failure, a common and distinct entity it is suggested be termed cannabinoid hyperemesis acute renal failure (CHARF). Expand
Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse
TLDR
It is concluded that chronic cannabis abuse was the cause of the cyclical vomiting illness in all cases, including the previously described case of psychogenic vomiting. Expand
Case of cannabinoid hyperemesis syndrome with long-term follow-up.
TLDR
Physicians should have a high index of suspicion for this under-recognized condition, as excellent long-term prognosis of CHS can be achieved when abstinence is maintained. Expand
Cannabinoid-Induced Hyperemesis: A Conundrum—From Clinical Recognition to Basic Science Mechanisms
TLDR
Human and animal findings suggest that chronic exposure to cannabis may not be a prerequisite for the induction of vomiting but is required for the intensity of emesis. Expand
[Cannabinoid hyperemesis syndrome inducing acute prerenal failure and electrolyte disturbance].
TLDR
Recreational use of cannabis is widespread and may induce a widely unknown syndrome characterized by nausea, vomiting and crampy abdominal pain accompanied by frequent hot showers or bathing that should be recognized as a potential cause of acute prerenal failure. Expand
Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatment—a Systematic Review
TLDR
Cannabinoid hyperemesis syndrome is a cyclic vomiting syndrome, preceded by daily to weekly cannabis use, usually accompanied by symptom improvement with hot bathing, and resolution with cessation of cannabis, which appears to be the best treatment. Expand
...
1
2
3
4
...