Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint

@inproceedings{Burston2013CannabinoidCR,
  title={Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint},
  author={J. J. Burston and Devi Rani Sagar and Pin Shao and Mingfeng Bai and Emma King and Louis Brailsford and Jenna M. Turner and Gareth J Hathway and Andrew J. Bennett and David Walsh and David A. Kendall and Aron H. Lichtman and V. Chapman},
  booktitle={PloS one},
  year={2013}
}
Osteoarthritis (OA) of the joint is a prevalent disease accompanied by chronic, debilitating pain. Recent clinical evidence has demonstrated that central sensitization contributes to OA pain. An improved understanding of how OA joint pathology impacts upon the central processing of pain is crucial for the identification of novel analgesic targets/new therapeutic strategies. Inhibitory cannabinoid 2 (CB2) receptors attenuate peripheral immune cell function and modulate central neuro-immune… CONTINUE READING