Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis

@article{Deveaux2009CannabinoidCR,
  title={Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis},
  author={Vanessa Deveaux and Thomas Cadoudal and Yasukatsu Ichigotani and Fatima Teixeira-Clerc and Alexandre Louvet and Sylvie Manin and Jeanne Tran-Van Nhieu and Marie Pierre Belot and Andreas Zimmer and Patrick Even and Patrice D Cani and Claude Knauf and Remy Burcelin and Adeline Bertola and Yannick Le Marchand-Brustel and Philippe Gual and Ariane Mallat and Sophie Lotersztajn},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={881 - 887}
}
BACKGROUND Obesity-associated inflammation is of critical importance in the development of insulin resistance and non-alcoholic fatty liver disease. Since the cannabinoid receptor CB2 regulates innate immunity, the aim of the present study was to investigate its role in obesity-induced inflammation, insulin resistance and fatty liver. METHODOLOGY Murine obesity models included genetically leptin-deficient ob/ob mice and wild type (WT) mice fed a high fat diet (HFD), that were compared to… CONTINUE READING
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