Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence

@article{Lisboa2015CannabinoidCR,
  title={Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence},
  author={Sabrina Francesca Lisboa and Anna A. Borges and Priscila Nejo and Aline Fassini and Leonardo B. M. Resstel},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2015},
  volume={59},
  pages={76-83}
}
Endocannabinoids (ECBs) such as anandamide (AEA) act by activating cannabinoid type 1 (CB1) or 2 (CB2) receptors. The anxiolytic effect of drugs that facilitate ECB effects is associated with increase in AEA levels in several encephalic areas, including the prefrontal cortex (PFC). Activation of CB1 receptors by CB1 agonists injected directly into these areas is usually anxiolytic. However, depending on the encephalic region being investigated and on the stressful experiences, opposite effects… CONTINUE READING

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