Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse.

@article{Cossu2001CannabinoidCR,
  title={Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse.},
  author={Gregorio Cossu and Catherine A. Ledent and L Fattore and Assunta Imperato and Georg Andrees B{\"o}hme and Marc Parmentier and Walter Fratta},
  journal={Behavioural brain research},
  year={2001},
  volume={118 1},
  pages={61-5}
}
The rewarding effects of morphine, cocaine, amphetamine and nicotine were evaluated in CB1 receptor knockout mice by means of an intravenous self-administration model. Experiments were carried out on drug-naive animals using a nose-poking response (NPR)-like as operandum. The results of the present study indicate that morphine did not induce intravenous self-administration in mutant CB1 receptor knockout mice, whereas it was significantly self-administered by the corresponding wild type mice… CONTINUE READING
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