Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats

  title={Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats},
  author={Maria Paola German{\`o} and Valeria D'Angelo and Maria Rita Mondello and Simona Pergolizzi and Francesco Capasso and Raffaele Capasso and Angelo A. Izzo and Nicola Mascolo and Rita De Pasquale},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
Abstract. The effect of cannabinoid drugs (i.p.) on cold/restraint stress-induced gastric ulcers was studied in rats. The cannabinoid receptor agonist (WIN 55,212-2, 0.1–1 mg/kg), but not the less active isomer WIN 55,212-3 (1 mg/kg), reduced gastric ulceration. The protective effect of WIN 55,212-2 (1 mg/kg) was counteracted by the cannabinoid CB1 receptor antagonist SR141716A, but not by the cannabinoid CB2 receptor antagonist SR144528. These results indicate that the antiulcer effect of the… 
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  • O. Abdel-Salam
  • Biology, Medicine
    Asian Pacific journal of tropical medicine
  • 2016
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SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor.
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