Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats

@article{German2000CannabinoidCI,
  title={Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats},
  author={Maria Paola German{\`o} and Valeria D'Angelo and Maria Rita Mondello and Simona Pergolizzi and Francesco Capasso and Raffaele Capasso and Angelo A. Izzo and Nicola Mascolo and Rita De Pasquale},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2000},
  volume={363},
  pages={241-244}
}
Abstract. The effect of cannabinoid drugs (i.p.) on cold/restraint stress-induced gastric ulcers was studied in rats. The cannabinoid receptor agonist (WIN 55,212-2, 0.1–1 mg/kg), but not the less active isomer WIN 55,212-3 (1 mg/kg), reduced gastric ulceration. The protective effect of WIN 55,212-2 (1 mg/kg) was counteracted by the cannabinoid CB1 receptor antagonist SR141716A, but not by the cannabinoid CB2 receptor antagonist SR144528. These results indicate that the antiulcer effect of the… 
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64 Citations
Highly Influential Citations
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64 Citations

Effects of Cannabinoid Receptor Agonists on Rat Gastric Acid Secretion: Discrepancy Between In Vitro and In Vivo Data
TLDR
In vitro and in vivo data indicate that CB1 receptors are not located on parietal cells but, rather, on vagal pathways (possibly at preganglionic sites) supplying the gastric mucosa, and the lack of effect of CB-receptor ligands in vitro cannot be ascribed to the use of immature rats.
Gastric antisecretory effects of synthetic cannabinoids after central or peripheral administration in the rat
Cannabinoid‐induced delayed gastric emptying is selectively increased upon intermittent administration in the rat: role of CB1 receptors
TLDR
The effect of intermittent treatment with the CB1/CB2 cannabinoid agonist WIN55,212‐2 (WIN) was studied in the rat and it was found that these effects might be modified upon repeated administration.
Cannabinoids in acute gastric damage and pancreatitis.
TLDR
Activation of CB1 receptors evokes opposite effects in the stomach and pancreas: inThe stomach, exhibits protective effect against stress-induced gastric mucosal lesions; whereas in the Pancreas, increases the severity of cerulein-induced pancreatitis.
CB1 positive allosteric modulation attenuates Δ9-THC withdrawal and NSAID-induced gastric inflammation
Stress differentially modulates behavioral responses to the cannabinoid agonist, WIN 55,212-2, in adult rats
TLDR
The main finding was that only in restraint stressed animals the administration of the CB 1 receptor agonist – WIN 55,212-2 – was able to interact with stress to alter the behavior of adult rats, indicating that stress differentially modulates behavioral responses to this cannabinoid agonist in the elevated plus maze.
Gastric acid inhibitory and gastric protective effects of Cannabis and cannabinoids.
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  • 2016
Angiotensin II-induced activation of central AT1 receptors exerts endocannabinoid-mediated gastroprotective effect in rats
Highly selective CB2 receptor agonist A836339 has gastroprotective effect on experimentally induced gastric ulcers in mice
TLDR
Activation of CB2 receptors exhibited gastroprotective effect through enhancement of anti-oxidative pathways in the stomach, as demonstrated by reduced H2O2 levels and increased CAT and SOD activities.
Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach
TLDR
The results indicate that gastric antisecretory effects of cannabinoids in the rat are mediated by suppression of vagal drive to the stomach through activation of CB1 receptors, located on pre‐ and postganglionic cholinergic pathways.
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