Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy.

@article{Mukhopadhyay2010Cannabinoid2RL,
  title={Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy.},
  author={Partha Mukhopadhyay and Mohanraj Rajesh and Hao Pan and Vivek A Patel and Bani Mukhopadhyay and S{\'a}ndor B{\'a}tkai and Bin Gao and Gy{\"o}rgy Hask{\'o} and P{\'a}l Pacher},
  journal={Free radical biology & medicine},
  year={2010},
  volume={48 3},
  pages={457-67}
}
Cisplatin is an important chemotherapeutic agent; however, its nephrotoxicity limits its clinical use. Enhanced inflammatory response and oxidative/nitrosative stress seem to play a key role in the development of cisplatin-induced nephropathy. Activation of cannabinoid-2 (CB(2)) receptors with selective agonists exerts anti-inflammatory and tissue-protective effects in various disease models. We have investigated the role of CB(2) receptors in cisplatin-induced nephrotoxicity using the… CONTINUE READING