Corpus ID: 37925522

Cannabinoid ( CB ) 1 receptors are critical for the innate immune response to TLR 4 stimulation

@inproceedings{Duncan2013CannabinoidC,
  title={Cannabinoid ( CB ) 1 receptors are critical for the innate immune response to TLR 4 stimulation},
  author={Marnie Duncan and Michael A. Galic and Arthur Goh Jin Wang and Adam P. Chambers and Donna-Marie McCafferty and Derek M McKay and Keith A Sharkey and Quentin J Pittman},
  year={2013}
}
Sickness behaviours are host defence adaptations that arise from integrated autonomic outputs in response to activation of the innate immune system. These behaviours include fever, anorexia, and hyperalgesia intended to promote survival of the host when encountering pathogens. Cannabinoid (CB) receptor activation can induce hypothermia and attenuate lipopolysaccharide (LPS)-evoked fever. The aim of the present study was to examine the role of CB1 receptors in the LPS-evoked febrile response… CONTINUE READING

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