Cannabinoid (CB)1 receptor antagonist, AM 251, causes a sustained reduction of daily food intake in the rat.

@article{Chambers2004CannabinoidR,
  title={Cannabinoid (CB)1 receptor antagonist, AM 251, causes a sustained reduction of daily food intake in the rat.},
  author={Adam P. Chambers and Keith A Sharkey and Henry S Koopmans},
  journal={Physiology & behavior},
  year={2004},
  volume={82 5},
  pages={863-9}
}
Cannabinoid (CB)(1) receptors are present throughout the nervous system, including several areas implicated in the control of food intake. Central and peripheral administration of CB(1) agonists increase food intake while CB(1) receptor antagonists reduce food intake. However, in some previous studies, tolerance to the anorectic effects of CB(1) antagonists develops within days. To further delineate the role of endogenous cannabinoid signaling in energy intake, we studied the effects of the CB… CONTINUE READING
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