Cannabinoid–Opioid Interaction in Chronic Pain

  title={Cannabinoid–Opioid Interaction in Chronic Pain},
  author={Donald I. Abrams and Paul Couey and Starley B. Shade and Mary Ellen Kelly and Neal L. Benowitz},
  journal={Clinical Pharmacology \& Therapeutics},
Cannabinoids and opioids share several pharmacologic properties and may act synergistically. The potential pharmacokinetics and the safety of the combination in humans are unknown. We therefore undertook a study to answer these questions. Twenty–one individuals with chronic pain, on a regimen of twice–daily doses of sustained–release morphine or oxycodone were enrolled in the study and admitted for a 5–day inpatient stay. Participants were asked to inhale vaporized cannabis in the evening of… 

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