Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis.

@article{Takeda2008CannabidiolicAA,
  title={Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis.},
  author={Shuso Takeda and Koichiro Misawa and Ikuo Yamamoto and Kazuhito Watanabe},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2008},
  volume={36 9},
  pages={1917-21}
}
In the present study it was revealed that cannabidiolic acid (CBDA) selectively inhibited cyclooxygenase (COX)-2 activity with an IC(50) value (50% inhibition concentration) around 2 microM, having 9-fold higher selectivity than COX-1 inhibition. In contrast, Delta(9)-tetrahydrocannabinolic acid (Delta(9)-THCA) was a much less potent inhibitor of COX-2 (IC(50) > 100 microM). Nonsteroidal anti-inflammatory drugs containing a carboxyl group in their chemical structures such as salicylic acid are… CONTINUE READING