Cannabidiolic‐acid synthase, the chemotype‐determining enzyme in the fiber‐type Cannabis sativa

@article{Taura2007CannabidiolicacidST,
  title={Cannabidiolic‐acid synthase, the chemotype‐determining enzyme in the fiber‐type Cannabis sativa},
  author={F. Taura and S. Sirikantaramas and Y. Shoyama and Kazuyoshi Yoshikai and S. Morimoto},
  journal={FEBS Letters},
  year={2007},
  volume={581}
}
Cannabidiolic‐acid (CBDA) synthase is the enzyme that catalyzes oxidative cyclization of cannabigerolic‐acid into CBDA, the dominant cannabinoid constituent of the fiber‐type Cannabis sativa. We cloned a novel cDNA encoding CBDA synthase by reverse transcription and polymerase chain reactions with degenerate and gene‐specific primers. Biochemical characterization of the recombinant enzyme demonstrated that CBDA synthase is a covalently flavinylated oxidase. The structural and functional… Expand
122 Citations
Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway
  • 77
  • PDF
Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides
  • 144
  • Highly Influenced
  • PDF
Daurichromenic Acid-producing Oxidocyclase in the Young Leaves of Rhododendron dauricum
  • 9
Engineering yeasts as platform organisms for cannabinoid biosynthesis.
  • 34
PKS activities and biosynthesis of cannabinoids and flavonoids in Cannabis sativa L. plants.
  • 38
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 30 REFERENCES
Purification and Characterization of Cannabidiolic-acid Synthase from Cannabis sativa L.
  • 96
  • PDF
The Gene Controlling Marijuana Psychoactivity
  • 166
  • PDF
Biosynthesis of cannabinoid acids
  • 80
Crystallization of Delta1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa.
  • 23
  • PDF
Characterization and Mechanism of the Berberine Bridge Enzyme, a Covalently Flavinylated Oxidase of Benzophenanthridine Alkaloid Biosynthesis in Plants (*)
  • 123
  • PDF
Cannabinoid pharmacology: the first 66 years
  • R. Pertwee
  • Medicine
  • British journal of pharmacology
  • 2006
  • 449
  • PDF
Cannabinerolic acid, a cannabinoid from Cannabis sativa
  • 21
Molecular characterization of a peripheral receptor for cannabinoids
  • 4,274
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
  • 4,460
...
1
2
3
...