Cannabidiolic‐acid synthase, the chemotype‐determining enzyme in the fiber‐type Cannabis sativa

@article{Taura2007CannabidiolicacidST,
  title={Cannabidiolic‐acid synthase, the chemotype‐determining enzyme in the fiber‐type Cannabis sativa},
  author={F. Taura and S. Sirikantaramas and Y. Shoyama and Kazuyoshi Yoshikai and S. Morimoto},
  journal={FEBS Letters},
  year={2007},
  volume={581}
}
Cannabidiolic‐acid (CBDA) synthase is the enzyme that catalyzes oxidative cyclization of cannabigerolic‐acid into CBDA, the dominant cannabinoid constituent of the fiber‐type Cannabis sativa. We cloned a novel cDNA encoding CBDA synthase by reverse transcription and polymerase chain reactions with degenerate and gene‐specific primers. Biochemical characterization of the recombinant enzyme demonstrated that CBDA synthase is a covalently flavinylated oxidase. The structural and functional… Expand
125 Citations

Paper Mentions

Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway
Daurichromenic Acid-producing Oxidocyclase in the Young Leaves of Rhododendron dauricum
Engineering yeasts as platform organisms for cannabinoid biosynthesis.
PKS activities and biosynthesis of cannabinoids and flavonoids in Cannabis sativa L. plants.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 30 REFERENCES
Purification and Characterization of Cannabidiolic-acid Synthase from Cannabis sativa L.
The Gene Controlling Marijuana Psychoactivity
Biosynthesis of cannabinoid acids
Crystallization of Delta1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa.
Cannabinoid pharmacology: the first 66 years
  • R. Pertwee
  • Medicine
  • British journal of pharmacology
  • 2006
Cannabinerolic acid, a cannabinoid from Cannabis sativa
Molecular characterization of a peripheral receptor for cannabinoids
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
...
1
2
3
...