Cannabidiol reduces ethanol consumption, motivation and relapse in mice.

  title={Cannabidiol reduces ethanol consumption, motivation and relapse in mice.},
  author={Adri{\'a}n Viudez-Mart{\'i}nez and Mar{\'i}a Salud Garc{\'i}a-Guti{\'e}rrez and Carmen Mar{\'i}a Navarr{\'o}n and Mar{\'i}a Isabel Morales-Calero and Francisco Navarrete and Ana Isabel Torres-Su{\'a}rez and Jorge Manzanares},
  journal={Addiction biology},
  volume={23 1},
This study evaluated the effects of cannabidiol (CBD) on ethanol reinforcement, motivation and relapse in C57BL/6 J mice. The effects of CBD (60 mg/kg, i.p.) on blood ethanol concentration, hypothermia and handling-induced convulsions associated to acute ethanol administration were evaluated. The two-bottle choice paradigm was performed to assess the effects of CBD (30, 60 and 120 mg/kg/day, i.p.) on ethanol intake and preference. In addition, an oral ethanol self-administration experiment was… CONTINUE READING
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