Cannabidiol reduces ethanol consumption, motivation and relapse in mice

@article{ViudezMartnez2018CannabidiolRE,
  title={Cannabidiol reduces ethanol consumption, motivation and relapse in mice},
  author={A. Viudez-Mart{\'i}nez and M. Garc{\'i}a-Guti{\'e}rrez and C. Navarr{\'o}n and M. Morales‐Calero and F. Navarrete and A. I. Torres-Su{\'a}rez and J. Manzanares},
  journal={Addiction Biology},
  year={2018},
  volume={23},
  pages={154–164}
}
  • A. Viudez-Martínez, M. García-Gutiérrez, +4 authors J. Manzanares
  • Published 2018
  • Psychology, Medicine
  • Addiction Biology
  • This study evaluated the effects of cannabidiol (CBD) on ethanol reinforcement, motivation and relapse in C57BL/6 J mice. The effects of CBD (60 mg/kg, i.p.) on blood ethanol concentration, hypothermia and handling-induced convulsions associated to acute ethanol administration were evaluated. The two-bottle choice paradigm was performed to assess the effects of CBD (30, 60 and 120 mg/kg/day, i.p.) on ethanol intake and preference. In addition, an oral ethanol self-administration experiment was… CONTINUE READING

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