Cannabidiol promotes browning in 3T3-L1 adipocytes

@article{Parray2016CannabidiolPB,
  title={Cannabidiol promotes browning in 3T3-L1 adipocytes},
  author={Hilal Ahmad Parray and Jong Won Yun},
  journal={Molecular and Cellular Biochemistry},
  year={2016},
  volume={416},
  pages={131-139}
}
Recruitment of the brown-like phenotype in white adipocytes (browning) and activation of existing brown adipocytes are currently being investigated as a means to combat obesity. [] Key Result CBD enhanced expression of a core set of brown fat-specific marker genes (Ucp1, Cited1, Tmem26, Prdm16, Cidea, Tbx1, Fgf21, and Pgc-1α) and proteins (UCP1, PRDM16, and PGC-1α).
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28 Citations
Background Citations
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Results Citations
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28 Citations

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L‐rhamnose induces browning in 3T3‐L1 white adipocytes and activates HIB1B brown adipocytes
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This is the first study to demonstrate that L‐rhamnose plays multiple modulatory roles in the induction of white fat browning, activation of brown adipocytes, as well as promotion of lipid metabolism, thereby demonstrating its therapeutic potential for treatment of obesity.
Gallotannin derivatives from mango ( Mangifera indica L.) suppress adipogenesis and increase thermogenesis in 3T3-L1 adipocytes in part through the AMPK pathway
The Mechanism of Leptin on Inhibiting Fibrosis and Promoting Browning of White Fat by Reducing ITGA5 in Mice
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Overall, the research shows that leptin can inhibit the activation of phosphatidylinositol 3 kinase (PI3K)-protein kinase B (AKT) signaling pathway by reducing the expression of ITGA5, which could alleviate adipose tissue fibrosis, and further promote white fat browning.
Histone H3 Methyltransferase Ezh2 Promotes White Adipocytes but inhibits Brown and Beige Adipocyte Differentiation in Mice.
Therapeutic efficacy of 6-Gingerol and 6-Shogaol in promoting browning of white adipocytes vis-à-vis enhanced thermogenesis portrayed in high fat milieu
Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol
TLDR
The pharmacological properties of CBD are highlighted as well as its impact on obesity in different tissues in a review of potential therapeutic properties of Cannabis derivatives.
A nutritional perspective on UCP1-dependent thermogenesis.
Recent developments in natural products for white adipose tissue browning.
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