Cannabidiol prevents lipopolysaccharide-induced sickness behavior and alters cytokine and neurotrophic factor levels in the brain

@article{Tito2021CannabidiolPL,
  title={Cannabidiol prevents lipopolysaccharide-induced sickness behavior and alters cytokine and neurotrophic factor levels in the brain},
  author={Pedro Augusto Lopes Tito and T{\'u}lio C{\'e}zar de Souza Bernardino and Paula Maria Quaglio Bellozi and Maria Carolina Machado da Silva and Aline Silva de Miranda and {\'E}rica Leandro Marciano Vieira and Fabr{\'i}cio A. Moreira and Andr{\'a}s Palot{\'a}s and Ant{\^o}nio Carlos Pinheiro de Oliveira and Helton Jos{\'e} Reis},
  journal={Pharmacological Reports},
  year={2021},
  volume={73},
  pages={1680 - 1693}
}
Background Major depressive disorder (MDD) affects millions of people worldwide. While the exact pathogenesis is yet to be elucidated, the role of neuro-immune signaling has recently emerged. Despite major advances in pharmacotherapy, antidepressant use is marred by limited efficacy and potential side effects. Cannabidiol (CBD), a phytocannabinoid, exerts antidepressant-like effects in experimental animals. This study investigated the impact of CBD on sickness behavior (SB), a measure of… 

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The hypothesis that the anticonvulsant effect of CBD involves PI3K in a seizure model induced by pentylenetetrazole (PTZ) is tested and its effects on seizure duration, latency, and number are quantified.

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