Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats

@article{Klein2011CannabidiolP,
  title={Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats},
  author={Charlotte Klein and E. Karanges and A. Spiro and A. Wong and J. Spencer and T. Huynh and N. Gunasekaran and T. Karl and L. E. Long and X. Huang and K. Liu and J. Arnold and I. McGregor},
  journal={Psychopharmacology},
  year={2011},
  volume={218},
  pages={443-457}
}
RationaleThe interactions between Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) during chronic treatment, and at equivalent doses, are not well characterised in animal models.ObjectivesThe aim of this study is to examine whether the behavioural effects of THC, and blood and brain THC levels are affected by pre-treatment with equivalent CBD doses.MethodsAdolescent rats were treated with ascending daily THC doses over 21 days (1 then 3 then 10 mg/kg). Some rats were given equivalent CBD… Expand
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