Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats

@article{Klein2011CannabidiolP,
  title={Cannabidiol potentiates $\Delta$9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats},
  author={Charlotte Klein and Emily A Karanges and Adena S. Spiro and Alexander Wong and Jarrah R. Spencer and Thanh Huynh and Nathan Gunasekaran and Tim Karl and Leonora E. Long and Xu-Feng Huang and Kelly Liu and Jonathon C Arnold and Iain S. McGregor},
  journal={Psychopharmacology},
  year={2011},
  volume={218},
  pages={443-457}
}
RationaleThe interactions between Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) during chronic treatment, and at equivalent doses, are not well characterised in animal models.ObjectivesThe aim of this study is to examine whether the behavioural effects of THC, and blood and brain THC levels are affected by pre-treatment with equivalent CBD doses.MethodsAdolescent rats were treated with ascending daily THC doses over 21 days (1 then 3 then 10 mg/kg). Some rats were given equivalent CBD… 
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The authors observed increased anxiety-like behavior in rats induced by THC alone and with CBD pretreatment and considered that these results were in “notable contrast” to former studies that found anxiolytic properties of CBD, including from the authors' group.
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TLDR
These data suggest that chronic exposure to THC during adolescence leads to some of the behavioral abnormalities common in schizophrenia, and support the hypothesis that adolescent THC use can impart long-term behavioral deficits; however, cotreatment with CBD prevents these deficits.
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TLDR
The immediate and long-term behavioral consequences of THC, CBD, and their combination in a mouse model of adolescent cannabis use are examined in order to better understand the interactions between CBD and THC in the neurodevelopmental effects of THC.
Effects of Chronic Exposure to Low-Dose delta-9-Tetrahydrocannabinol in Adolescence and Adulthood on Serotonin/Norepinephrine Neurotransmission and Emotional Behavior
TLDR
Chronic low-dose THC exposure during the critical developmental period of adolescence and during adulthood could result in increased vulnerability of the serotonin system accompanied by anxiety symptoms, underscoring the greater vulnerability of young ages to the mental effects of cannabis.
Cannabidiol modulation of antinociceptive tolerance to Δ9-tetrahydrocannabinol
TLDR
The decrease in THC’s antinociceptive effects after repeated CBD exposure may be due to CBD-induced inhibition of THC metabolism, and/or antagonism of THC effects that emerges with repeated CBD treatment.
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