Cannabidiol modifies the seizure expression and effects of antiseizure drugs in a rat model of recurrent severe seizures

  title={Cannabidiol modifies the seizure expression and effects of antiseizure drugs in a rat model of recurrent severe seizures},
  author={Christian Lizette Fr{\'i}as-Soria and Daniel P{\'e}rez-P{\'e}rez and Sandra Adela Orozco-Su{\'a}rez and Luisa L. Rocha},

Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures

The effects of chronic CBD administration in a mouse model of CLN1 disease (Cln1-/-) that simultaneously exhibits neuroinflammation, neurodegeneration, and spontaneous seizures are determined, consistent with CBD having immunomodulatory effects.

Cannabidiol Reduces Short- and Long-Term High Glutamate Release after Severe Traumatic Brain Injury and Improves Functional Recovery

Results support that orally administered CBD reduces short- and long-term TBI-induced excitotoxicity and facilitated functional recovery and pretreatment with CBD was sufficient to lessen the adverse sequelae of TBI.

Determination of the Chemical Composition and Antimicrobial Activity of Lavatera thuringiaca L. Medicinal Herb Material Extracted under Subcritical Conditions by the Liquid Carbon Dioxide Method

Antimicrobial activity studies have shown that the CO2 extract of Lavatera thuringiaca L. has high values of the growth suppression zone exceeding 15 mm, and has a pronounced effect against clinically significant microorganisms.



Neuronal and Glial Expression of the Multidrug Resistance Gene Product in an Experimental Epilepsy Model

A selective increase in Pgp-170 immunoreactivity is demonstrated in the brain capillary endothelial cells, astrocytes, and neurons during repetitive MP-induced seizures, demonstrating the role for this P gp-170 overexpression in endothelium and astroCytes as a clearance mechanism in the refractory epilepsy.

Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy

The findings demonstrate anticonvulsant and neuroprotective effects of CBD preventive treatment in the intrahippocampal pilocarpine epilepsy model, either as single or multiple administrations, reinforcing the potential role of CBD in the treatment of epileptic disorders.

Anticonvulsant effects of cannabinoids in mice: Drug interactions within cannabinoids and cannabinoid interactions with phenytoin

The administration of δ9-THC significantly potentiated the anticonvulsant effectiveness of phenytoin against electroshock seizures and this effect was further potentiated by the concurrent administration of CBD.

Neuronal lesions in mercaptopropionic acid-induced status epilepticus

It was concluded that mercaptopropionic acid-induced seizures cause permanent lesions to specific brain areas, with the most pronounced effect in the substantia nigra pars reticulata.

Cannabidiol--antiepileptic drug comparisons and interactions in experimentally induced seizures in rats.

  • P. ConsroeA. Wolkin
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1977
CBD is an effective anticonvulsant with a specificity more comparable to drugs clinically effective in major than minor seizures, and it appears that CBD enhances the anticonVulsant effects of the former and reduces the effects ofThe latter types of antiepileptic drugs.

Antiepileptic drug therapy.

  • M. Podell
  • Medicine, Psychology
    Clinical techniques in small animal practice
  • 1998