Cannabidiol is an effective helper compound in combination with bacitracin to kill Gram-positive bacteria

  title={Cannabidiol is an effective helper compound in combination with bacitracin to kill Gram-positive bacteria},
  author={Claes S{\o}ndergaard Wassmann and Peter H{\o}jrup and Janne Kudsk Klitgaard},
  journal={Scientific Reports},
The cannabinoid cannabidiol (CBD) is characterised in this study as a helper compound against resistant bacteria. CBD potentiates the effect of bacitracin (BAC) against Gram-positive bacteria ( Staphylococcus species, Listeria monocytogenes , and Enterococcus faecalis ) but appears ineffective against Gram-negative bacteria. CBD reduced the MIC value of BAC by at least 64-fold and the combination yielded an FIC index of 0.5 or below in most Gram-positive bacteria tested. Morphological changes… 

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  • D. Storm
  • Biology, Chemistry
    Annals of the New York Academy of Sciences
  • 1974
Since its discovery, it has been established that the bacitracin peptides inhibit the biosynthesis of bacterial cell walk, and a crucial step in cell wall biosynthesis, the enzymatic dephosphorylation of the C,, isoprenylpyrophosphate is inhibited.

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