Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule‐1

@article{Ramer2012CannabidiolIL,
  title={Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule‐1},
  author={Robert M. Ramer and Katharina Bublitz and Nadine Freimuth and Jutta Merkord and Helga Rohde and Maria Haustein and Philipp Borchert and Ellen Schmuhl and Michael Linnebacher and Burkhard Hinz},
  journal={The FASEB Journal},
  year={2012},
  volume={26},
  pages={1535 - 1548}
}
Cannabinoids inhibit cancer cell invasion via increasing tissue inhibitor of matrix metalloproteinases‐1 (TIMP‐1). This study investigates the role of intercellular adhesion molecule‐1 (ICAM‐1) within this action. In the lung cancer cell lines A549, H358, and H460, cannabidiol (CBD; 0.001‐3 μM) elicited concentration‐dependent ICAM‐1 up‐regulation compared to vehicle via cannabinoid receptors, transient receptor potential vanilloid 1, and p42/44 mitogen‐activated protein kinase. Up‐regulation… 

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