Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule‐1

  title={Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule‐1},
  author={Robert M. Ramer and Katharina Bublitz and Nadine Freimuth and Jutta Merkord and Helga Rohde and Maria Haustein and Philipp Borchert and Ellen Schmuhl and Michael Linnebacher and Burkhard Hinz},
  journal={The FASEB Journal},
  pages={1535 - 1548}
Cannabinoids inhibit cancer cell invasion via increasing tissue inhibitor of matrix metalloproteinases‐1 (TIMP‐1). This study investigates the role of intercellular adhesion molecule‐1 (ICAM‐1) within this action. In the lung cancer cell lines A549, H358, and H460, cannabidiol (CBD; 0.001‐3 μM) elicited concentration‐dependent ICAM‐1 up‐regulation compared to vehicle via cannabinoid receptors, transient receptor potential vanilloid 1, and p42/44 mitogen‐activated protein kinase. Up‐regulation… 

Downregulation of human intercellular adhesion molecule-1 attenuates the metastatic ability in human breast cancer cell lines.

The results showed that silencing of ICAM-1 can inhibit the metastatic ability of MCF-7 cell lines in vitro significantly, and the decreased migration and invasion was accompanied by a reduction of MMP-14.

Celecoxib increases lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1

Celecoxib-induced upregulation of ICAM-1 on lung cancer cells is demonstrated to be responsible for intercellular ICam-1/LFA-1 crosslink that confers increased cancer cell lysis by LAK cells, providing proof for a novel antitumorigenic mechanism of celecoxib.

Assessment of Cannabinoids Agonist and Antagonist in Invasion Potential of K562 Cancer Cells

The findings clarifies that CB1 receptors are responsible for anti-invasive effects in the K562 cell line and shows that WIN 55212-2 considerably reduced cancer cell invasiveness, while AM251 exhibited a converse effect.

Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression.

It is reported for the first time that CB2R signaling affects DC migration in vitro and in vivo, primarily through the inhibition of matrix metalloproteinase 9 (MMP-9) expression.

Cancer Therapeutic Insights COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells

Analysis of lung cancer cell lines and primary cells from a patient with lung cancer and nude mice shows a novel proapoptotic mechanism of cannabidiol involving initial upregulation of COX-2 and PPar-g and a subsequent nuclear translocation of PPAR-g by COx-2–dependent PGs.

ACPA decreases non-small cell lung cancer line growth through Akt/PI3K and JNK pathways in vitro

The results demonstrated that low dose ACPA and ACPA-PCL nanoparticle system harbor opportunities to be developed as a novel therapy in NSCLC patients that require further in vivo studies beforehand to validate its anticancer effect.

Anti-invasion Effects of Cannabinoids Agonist and Antagonist on Human Breast Cancer Stem Cells

The results did not show any correlation between reduced invasion and cytotoxic effects of the drug, since one of the main cancer recurrence factors is anti-cancer drugs fail to inhibit CSC population.

Up-regulation of heme oxygenase-1 expression and inhibition of disease-associated features by cannabidiol in vascular smooth muscle cells

This work provides the first indication of CBD-mediated enhancement of HO-1 in VSMC and potential protective effects against aberrant VSMC proliferation and migration.



Cisplatin up‐regulates ICAM‐1 expression in endothelial cell via a NF‐κB dependent pathway

Data suggest that ICAM‐1 involves in the pathophsiologic process of cisplatin‐induced vascular toxicity and may be exploited for therapeutic advantage.

A Novel Anticancer Effect of Thalidomide: Inhibition of Intercellular Adhesion Molecule-1–Mediated Cell Invasion and Metastasis through Suppression of Nuclear Factor-κB

These studies provide a framework for targeting ICAM-1 as a biologically based therapy for cancer, and thalidomide might be effective in human lung cancer.

Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1.

  • R. RamerB. Hinz
  • Biology, Medicine
    Journal of the National Cancer Institute
  • 2008
Increased expression of TIMP-1 mediates an anti-invasive effect of cannabinoids and may offer a therapeutic option in the treatment of highly invasive cancers.

Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells

The cannabinoid agonist WIN 55,212‐2 inhibited the proliferation of human gastric cancer cells in a dose‐dependent manner and that this effect was mediated partially by the CB1 receptor, and induced apoptosis and down‐regulation of the phospho‐AKT expression in human gastrics cancer cells.

Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.

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Upregulation of tissue inhibitor of matrix metalloproteinases-1 confers the anti-invasive action of cisplatin on human cancer cells

A hitherto unknown mechanism by which cisplatin exerts its antimetastatic properties on highly invasive cancer cells is demonstrated, with findings showing a concentration-dependent inhibition of Matrigel invasion by recombinant TIMP-1.

Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor‐suppressor efficacy

The results suggest that anandamide could be involved in the control of cancer growth targeting both tumor cell proliferation and the angiogenic stimulation of the vasculature.

Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells

Evidence for a hitherto unknown mechanism underlying the anti-invasive action of cannabidiol on human lung cancer cells is provided, suggesting a crucial role of PAI-1 in A549 invasiveness.

TGF-beta1 down-regulates ICAM-1 expression and enhances liver metastasis of pancreatic cancer.

The present results indicate that unknown function of TGF-beta1 in the tumor progression and metastasis of pancreatic cancer is indicated.

ICAM‐1 (Intercellular Adhesion Molecule‐1) Gene Transfection Inhibits Lymph Node Metastasis by Human Gastric Cancer Cells

The above findings indicate that ICAM‐1 gene transduction could prove to be an effective gene therapy for lymph node metastasis of gastric cancer.