Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule‐1

@article{Ramer2012CannabidiolIL,
  title={Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule‐1},
  author={Robert M. Ramer and Katharina Bublitz and Nadine Freimuth and Jutta Merkord and Helga Rohde and Maria Haustein and Philipp Borchert and Ellen Schmuhl and Michael Linnebacher and Burkhard Hinz},
  journal={The FASEB Journal},
  year={2012},
  volume={26},
  pages={1535 - 1548}
}
Cannabinoids inhibit cancer cell invasion via increasing tissue inhibitor of matrix metalloproteinases‐1 (TIMP‐1). This study investigates the role of intercellular adhesion molecule‐1 (ICAM‐1) within this action. In the lung cancer cell lines A549, H358, and H460, cannabidiol (CBD; 0.001‐3 μM) elicited concentration‐dependent ICAM‐1 up‐regulation compared to vehicle via cannabinoid receptors, transient receptor potential vanilloid 1, and p42/44 mitogen‐activated protein kinase. Up‐regulation… Expand

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References

SHOWING 1-10 OF 72 REFERENCES
Cisplatin up‐regulates ICAM‐1 expression in endothelial cell via a NF‐κB dependent pathway
TLDR
Data suggest that ICAM‐1 involves in the pathophsiologic process of cisplatin‐induced vascular toxicity and may be exploited for therapeutic advantage. Expand
Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1.
TLDR
Findings provide a novel mechanism underlying the anti-invasive action of cannabidiol and imply its use as a therapeutic option for the treatment of highly invasive cancers. Expand
A Novel Anticancer Effect of Thalidomide: Inhibition of Intercellular Adhesion Molecule-1–Mediated Cell Invasion and Metastasis through Suppression of Nuclear Factor-κB
TLDR
These studies provide a framework for targeting ICAM-1 as a biologically based therapy for cancer, and thalidomide might be effective in human lung cancer. Expand
Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1.
  • R. Ramer, B. Hinz
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • 2008
TLDR
Increased expression of TIMP-1 mediates an anti-invasive effect of cannabinoids and may offer a therapeutic option in the treatment of highly invasive cancers. Expand
Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells
TLDR
The cannabinoid agonist WIN 55,212‐2 inhibited the proliferation of human gastric cancer cells in a dose‐dependent manner and that this effect was mediated partially by the CB1 receptor, and induced apoptosis and down‐regulation of the phospho‐AKT expression in human gastrics cancer cells. Expand
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.
TLDR
Manipulation of MMP-2 expression by RNA interference and cDNA overexpression experiments proved that down-regulation of this MMP plays a critical role in THC-mediated inhibition of cell invasion and constitutes a new hallmark of cannabinoid antitumoral activity. Expand
Upregulation of tissue inhibitor of matrix metalloproteinases-1 confers the anti-invasive action of cisplatin on human cancer cells
TLDR
A hitherto unknown mechanism by which cisplatin exerts its antimetastatic properties on highly invasive cancer cells is demonstrated, with findings showing a concentration-dependent inhibition of Matrigel invasion by recombinant TIMP-1. Expand
Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor‐suppressor efficacy
TLDR
The results suggest that anandamide could be involved in the control of cancer growth targeting both tumor cell proliferation and the angiogenic stimulation of the vasculature. Expand
Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells
TLDR
Evidence for a hitherto unknown mechanism underlying the anti-invasive action of cannabidiol on human lung cancer cells is provided, suggesting a crucial role of PAI-1 in A549 invasiveness. Expand
TGF-beta1 down-regulates ICAM-1 expression and enhances liver metastasis of pancreatic cancer.
TLDR
The present results indicate that unknown function of TGF-beta1 in the tumor progression and metastasis of pancreatic cancer is indicated. Expand
...
1
2
3
4
5
...