Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression.

@article{Mckallip2006CannabidiolinducedAI,
  title={Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression.},
  author={Robert J. Mckallip and Wentao Jia and Jerome J. Schlomer and James W Warren and Prakash Nagarkatti and Mitzi Nagarkatti},
  journal={Molecular pharmacology},
  year={2006},
  volume={70 3},
  pages={897-908}
}
In the current study, we examined the effects of the nonpsychoactive cannabinoid, cannabidiol, on the induction of apoptosis in leukemia cells. Exposure of leukemia cells to cannabidiol led to cannabinoid receptor 2 (CB2)-mediated reduction in cell viability and induction in apoptosis. Furthermore, cannabidiol treatment led to a significant decrease in tumor burden and an increase in apoptotic tumors in vivo. From a mechanistic standpoint, cannabidiol exposure resulted in activation of caspase… CONTINUE READING
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A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol

  • E Russo
  • Med Hypotheses
  • 2006
1 Excerpt

Functional analysis of Nox4 reveals unique characteristics compared with other NADPH oxidases

  • KD Martyn, LM Frederick, K von Loehneysen, MC Dinauer, UG Knaus
  • Cell Signal 18:69–82
  • 2006
2 Excerpts

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