Cannabidiol in Anxiety and Sleep: A Large Case Series.
@article{Shannon2019CannabidiolIA, title={Cannabidiol in Anxiety and Sleep: A Large Case Series.}, author={Scott M. Shannon and Nicole Lewis and Hea Eul Lee and Shannon Hughes}, journal={The Permanente journal}, year={2019}, volume={23}, pages={ 18-041 } }
CONTEXT
Cannabidiol (CBD) is one of many cannabinoid compounds found in cannabis. [] Key MethodDESIGN
A large retrospective case series at a psychiatric clinic involving clinical application of CBD for anxiety and sleep complaints as an adjunct to usual treatment. The retrospective chart review included monthly documentation of anxiety and sleep quality in 103 adult patients.
MAIN OUTCOME MEASURES
Sleep and anxiety scores, using validated instruments, at baseline and after CBD treatment.
192 Citations
Cannabidiol (CBD) use in psychiatric disorders: A systematic.
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Use of Cannabidiol for the Treatment of Anxiety: A Short Synthesis of Pre-Clinical and Clinical Evidence.
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Early evidence from human trials using both healthy volunteers and individuals with social anxiety disorder, suggests that CBD may have anxiolytic effects, and future research is warranted to determine the efficacy of CBD in other anxiety disorders, establish appropriate doses, and determine its long-term efficacy.
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The prospects of using the psychoactive effects of cannabinoids in treating mental and psychiatric disorders are discussed, however, this evidence is weak for some clinical conditions and well-designed randomized controlled trials are currently lacking.
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Until additional, well-designed studies that examine the more common practice of lower doses of CBD are performed, a harm-reduction, patient-centered, empiric approach is encouraged to optimize symptom reduction while at the same time avoiding the known risks of cannabis.
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The patient improved regarding depressive as well as anxiety symptoms including simple phobias and symptoms of paranoia and dissociation, and the patient quit abusing illegal drugs including THC without showing withdrawal symptoms.
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Based on this preclinical evidence, larger-scale placebo-controlled clinical studies are warranted to investigate the effects of cannabidiol in particular as an adjunct to psychological therapy or medication to determine its potential utility for treating anxiety-related disorders in the future.
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CBD and CBD-containing compounds such as nabiximols were helpful in alleviating symptoms of cannabis-related disorders, schizophrenia, social anxiety disorder, and comorbidities of ASD, and ADHD with moderate recommendation, however, there is weaker evidence for insomnia, anxiety, bipolar disorder, posttraumatic stress disorder and Tourette syndrome.
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A systematic review and meta-analysis of the literature on cannabis-based products for the treatment of insomnia disorder in adults highlights shortcomings in the existing literature, including lack of diagnostic clarity, poorly defined participant groups, non-standardised interventions and studies of inappropriate design, duration and power to detect clinically meaningful outcomes.
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