Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes.

@article{Olh2014CannabidiolES,
  title={Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes.},
  author={Attila Ol{\'a}h and Bal{\'a}zs Istv{\'a}n T{\'o}th and Istv{\'a}n Borb{\'i}r{\'o} and Koji Sugawara and Attila G{\'a}bor Sz{\"o}llősi and Gabriella Czifra and Bal{\'a}zs Zolt{\'a}n P{\'a}l and L{\'i}dia Ambrus and Jennifer Elisabeth Kloepper and Emanuela Camera and Matteo Ludovici and Mauro Picardo and Thomas Voets and Christos C. Zouboulis and Ralf Paus and Tam{\'a}s B{\'i}r{\'o}},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 9},
  pages={
          3713-24
        }
}
The endocannabinoid system (ECS) regulates multiple physiological processes, including cutaneous cell growth and differentiation. Here, we explored the effects of the major nonpsychotropic phytocannabinoid of Cannabis sativa, (-)-cannabidiol (CBD), on human sebaceous gland function and determined that CBD behaves as a highly effective sebostatic agent. Administration of CBD to cultured human sebocytes and human skin organ culture inhibited the lipogenic actions of various compounds, including… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 36 CITATIONS

TRPV4: Molecular Conductor of a Diverse Orchestra.

  • Physiological reviews
  • 2016
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Cannabinoids in dermatology: a scoping review.

  • Dermatology online journal
  • 2018
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Use of Cannabidiol in the Treat e t f ile s : Effic c rit i li i l

Serena Silvestro, Santa Mammana, Eugenio Cavalli, Placido Bramanti, Emanuela Mazzon
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

Cannabis Therapeutics and the Future of Neurology

  • Front. Integr. Neurosci.
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 80 REFERENCES

Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2008
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

New developments in our understanding of acne pathogenesis and treatment

I Kurokawa
  • Exp Dermatol
  • 2009
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Targeting the endocannabinoid system: to enhance or reduce?

  • Nature Reviews Drug Discovery
  • 2008
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Cannabinoid pharmacology: the first 66 years.

  • British journal of pharmacology
  • 2006
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL