Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease.

@article{MartnMoreno2011CannabidiolAO,
  title={Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease.},
  author={Ana Mar{\'i}a Mart{\'i}n-Moreno and David Reigada and Bel{\'e}n G Ram{\'i}rez and Raphael Mechoulam and Nadia G. Innamorato and Antonio Cuadrado and Maria L de Ceballos},
  journal={Molecular pharmacology},
  year={2011},
  volume={79 6},
  pages={964-73}
}
Microglial activation is an invariant feature of Alzheimer's disease (AD). It is noteworthy that cannabinoids are neuroprotective by preventing β-amyloid (Aβ)-induced microglial activation both in vitro and in vivo. On the other hand, the phytocannabinoid cannabidiol (CBD) has shown anti-inflammatory properties in different paradigms. In the present study, we compared the effects of CBD with those of other cannabinoids on microglial cell functions in vitro and on learning behavior and cytokine… CONTINUE READING
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