Cannabidiol and Cannabol, Constituents of Cannabis indica Resin

  title={Cannabidiol and Cannabol, Constituents of Cannabis indica Resin},
  author={A. Jacob and Alexander Robertus Todd},
IN a previous publication, Work, Bergel and Todd1described a method for the separation of cannabinol from Cannabis indica resin (hashish) of Indian origin as its crystalline p-nitrobenzoate. In the course of further work on hashish we have been able, through the co-operation of the Home Office (Drugs Branch), to examine a fresh specimen of the Egyptian drug. Application of the p-nitrobenzoylation process to the distilled resin from this material yielded a less soluble fraction consisting of… 
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Chemistry and pharmacology of cannabis.
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Cannabis has been used for centuries by a sector of society, either by inhalation or orally, without evoking enough scientific interest except probably as a minor problem of sociological and legal importance.
Chemistry of the Hemp Drugs
Of all the common addiction drugs, least of a scientific nature is known about Cannabis, and this despite the fact that it has quite remarkable pharmacological properties, the isolation and characterization of the active principle or principles might well prove of considerable medical importance.
Physiologically Active Fractions of Indian Hemp
IN spite of nearly fifty years of intensive study, the chemistry of hemp resin is still obscure. Earlier workers reported that the active ingredient of Indian hemp was not an alkaloid1 but a resin1,2
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Cannabis saliva L. (family Moraceae) is a dioecious plant of which two varieties exist, var. indica and var. non indica or typica. The flowering top of the female plant is covered with glandular
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Studies on cannabinoids that predate the identification of ∆9-THC as the intoxicating constituents of recreational cannabis by Raphael Mechoulam in 1964 are reviewed, critically analyzing the
Cannabidiol as the Substrate in Acid-Catalyzed Intramolecular Cyclization
The use of Lewis and protic acids in different solvents has been studied to investigate the possible modulation of the reactivity of CBD (cannabidiol) and the complete NMR spectroscopic characterizations of the four isomers are reported.
Intralaboratory comparison of analytical methods for quantification of major phytocannabinoids
Three chromatographic analytical methods were evaluated regarding selectivity, sensitivity, analytical accuracy, and precision and all three methods were demonstrated to be appropriate tools for analyzing phytocannabinoids in cannabis.
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The integrated inventory of these compounds and their biological macromolecular end-points highlights the opportunities that phytocannabinoids offer to access desirable drug-like space beyond the one associated to the narcotic target CB1.
It is critical to the scientific coniniunity that a document fully elucidating the current state of the knou-ledge of naturally occurring constituent< in Caiznabis be published.
Alkohole, Phenole, Naphthole
Sehr zahlreiche Alkohole und Phenole finden sich weit verbreitet im Pflanzenreich, und zwar z. T. frei, zum uberwiegenden Teil aber in ather- oder esterartiger Bindung. In grosster Menge kommt das