Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels

@article{Ryan2009CannabidiolTM,
  title={Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels},
  author={D. Ryan and A. J. Drysdale and C. Lafourcade and R. Pertwee and B. Platt},
  journal={The Journal of Neuroscience},
  year={2009},
  volume={29},
  pages={2053 - 2063}
}
  • D. Ryan, A. J. Drysdale, +2 authors B. Platt
  • Published 2009
  • Medicine, Biology
  • The Journal of Neuroscience
  • Cannabinoids and the endocannabinoid system have attracted considerable interest for therapeutic applications. Nevertheless, the mechanism of action of one of the main nonpsychoactive phytocannabinoids, cannabidiol (CBD), remains elusive despite potentially beneficial properties as an anti-convulsant and neuroprotectant. Here, we characterize the mechanisms by which CBD regulates Ca2+ homeostasis and mediates neuroprotection in neuronal preparations. Imaging studies in hippocampal cultures… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 88 REFERENCES
    Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells
    • 75
    Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue
    • 22
    CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons.
    • 75
    Cannabinoids: mechanisms and therapeutic applications in the CNS.
    • 43
    Mitochondrial Ca2+ Uptake Requires Sustained Ca2+ Release from the Endoplasmic Reticulum*
    • 84
    • PDF
    Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants.
    • 525
    • PDF
    Neuropharmacology and therapeutic potential of cannabinoids
    • 68