• DOI:10.1523/JNEUROSCI.4212-08.2009
Corpus ID: 4847548

Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels

@article{Ryan2009CannabidiolTM,
  title={Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels},
  author={D. Ryan and A. J. Drysdale and C. Lafourcade and R. Pertwee and B. Platt},
  journal={The Journal of Neuroscience},
  year={2009},
  volume={29},
  pages={2053 - 2063}
}

D. Ryan, A. J. Drysdale, +2 authors B. Platt

Published 2009

Medicine, Biology

The Journal of Neuroscience

Cannabinoids and the endocannabinoid system have attracted considerable interest for therapeutic applications. Nevertheless, the mechanism of action of one of the main nonpsychoactive phytocannabinoids, cannabidiol (CBD), remains elusive despite potentially beneficial properties as an anti-convulsant and neuroprotectant. Here, we characterize the mechanisms by which CBD regulates Ca2+ homeostasis and mediates neuroprotection in neuronal preparations. Imaging studies in hippocampal cultures… CONTINUE READING

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