Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels
@article{Ryan2009CannabidiolTM, title={Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels}, author={Duncan Ryan and Alison J. Drysdale and Carlos Lafourcade and Roger G. Pertwee and Bettina Platt}, journal={The Journal of Neuroscience}, year={2009}, volume={29}, pages={2053 - 2063} }
Cannabinoids and the endocannabinoid system have attracted considerable interest for therapeutic applications. Nevertheless, the mechanism of action of one of the main nonpsychoactive phytocannabinoids, cannabidiol (CBD), remains elusive despite potentially beneficial properties as an anti-convulsant and neuroprotectant. Here, we characterize the mechanisms by which CBD regulates Ca2+ homeostasis and mediates neuroprotection in neuronal preparations. Imaging studies in hippocampal cultures…
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