Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats

  title={Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats},
  author={Fernanda F Peres and Raquel R. Levin and Mayra Akimi Suiama and Mariana Cepollaro Diana and Douglas Albuquerque Gouv{\^e}a and Val{\'e}ria de Almeida and Camila Maur{\'i}cio Santos and Lisandro Lungato and Antonio Waldo Zuardi and Jaime Eduardo Cecilio Hallak and Jos{\'e} Alexandre S. Crippa and D'almeida Vania and Regina Helena Silva and Vanessa C Ab{\'i}lio},
  journal={Frontiers in Pharmacology},
Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson’s disease patients, CBD is able to attenuate the psychotic symptoms induced by L-DOPA and to improve quality of life. Repeated administration of reserpine in rodents induces motor impairments that are accompanied by cognitive deficits, and has been applied to model both tardive dyskinesia and Parkinson’s disease. The… 

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