Cannabidiol Increases Proliferation, Migration, Tubulogenesis, and Integrity of Human Brain Endothelial Cells through TRPV2 Activation.

@article{Luo2019CannabidiolIP,
  title={Cannabidiol Increases Proliferation, Migration, Tubulogenesis, and Integrity of Human Brain Endothelial Cells through TRPV2 Activation.},
  author={Huilong Luo and E. Rossi and B. Saubam{\'e}a and Stéphanie Chasseigneaux and V. Cochois and Nina Choublier and M. Smirnova and F. Glacial and N. Perrière and S. Bourdoulous and D. Smadja and M. Menet and P. Couraud and S. Cisternino and X. Decl{\`e}ves},
  journal={Molecular pharmaceutics},
  year={2019},
  volume={16 3},
  pages={
          1312-1326
        }
}
The effect of cannabidiol (CBD), a high-affinity agonist of the transient receptor potential vanilloid-2 (TRPV2) channel, has been poorly investigated in human brain microvessel endothelial cells (BMEC) forming the blood-brain barrier (BBB). TRPV2 expression and its role on Ca2+ cellular dynamics, trans-endothelial electrical resistance (TEER), cell viability and growth, migration, and tubulogenesis were evaluated in human primary cultures of BMEC (hPBMEC) or in the human cerebral microvessel… Expand
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