Cannabidiol – Recent Advances

@article{Mechoulam2007CannabidiolR,
  title={Cannabidiol – Recent Advances},
  author={Raphael Mechoulam and Maximilian Peters and Eric Murillo-Rodr{\'i}guez and Lum{\'i}r Ondřej Hanu{\vs}},
  journal={Chemistry \& Biodiversity},
  year={2007},
  volume={4}
}
The aim of this review is to present some of the recent publications on cannabidiol (CBD; 2), a major non‐psychoactive constituent of Cannabis, and to give a general overview. Special emphasis is laid on biochemical and pharmacological advances, and on novel mechanisms recently put forward, to shed light on some of the pharmacological effects that can possibly be rationalized through these mechanisms. The plethora of positive pharmacological effects observed with CBD make this compound a highly… 
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429 Citations
Highly Influential Citations
18
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144
Methods Citations
5
Results Citations
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429 Citations

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References

SHOWING 1-10 OF 71 REFERENCES
Cannabidiol: An Overview of Some Pharmacological Aspects
TLDR
The authors present a review on the chemistry of CBD and discuss the anticonvulsive, antianxiety, antipsychotic, antinausea, and antirheumatoid arthritic properties of CBD.
Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects.
Synthesis of a primary metabolite of cannabidiol.
TLDR
This work reports the first total synthesis of 7-hydroxycannabidiol 2, a primary metabolite of cannABidiol, in an eight-step procedure, which produces numerous, potentially therapeutic pharmacological effects.
The Pharmacological Actions of Cannabidiol
TLDR
The current understanding of the mechanism of action of cannabidiol is discussed, focusing on some of the central and peripheral pharmacological effects of this exciting potential therapeutic agent.
New cannabidiol derivatives: synthesis, binding to cannabinoid receptor, and evaluation of their antiinflammatory activity.
TLDR
Surprisingly, it is found that hydrogenated CBD and CBD-DMH exhibit good binding to the cannabinoid receptor (CB(1), and demonstrate bioactivities different from their original compounds.
Synthesis of cannabidiols via alkenylation of cyclohexenyl monoacetate.
TLDR
The key reaction is nickel-catalyzed allylation of 2-cyclohexene-1,4-diol monoacetate with a new reagent, (alkenyl)ZnCl/TMEDA, which gives a S(N)2-type product with 94% regioselectivity in good yield.
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
TLDR
Results suggest that VR1 receptors, or increased levels of endogenous AEA, might mediate some of the pharmacological effects of CBD and its analogues, and (−)‐5′‐DMH‐CBD represents a valuable candidate for further investigation as inhibitor of AEA uptake and a possible new therapeutic agent.
A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol.
The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.
Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
TLDR
Evaluating the in vitro antiproliferative ability of cannabidiol (CBD), a nonpsychoactive cannabinoid compound, on U87 and U373 human glioma cell lines suggests a possible application of CBD as an antineoplastic agent.
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