Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury.

  title={Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury.},
  author={Ronen Durst and Haim Danenberg and Ruth Gallily and Raphael Mechoulam and Keren Meir and Etty Grad and Ronen Beeri and Thea Pugatsch and Elizabet Tarsish and Chaim Lotan},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={293 6},
  • R. DurstH. Danenberg C. Lotan
  • Published 1 December 2007
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
Cannabidiol (CBD) is a major, nonpsychoactive Cannabis constituent with anti-inflammatory activity mediated by enhancing adenosine signaling. Inasmuch as adenosine receptors are promising pharmaceutical targets for ischemic heart diseases, we tested the effect of CBD on ischemic rat hearts. For the in vivo studies, the left anterior descending coronary artery was transiently ligated for 30 min, and the rats were treated for 7 days with CBD (5 mg/kg ip) or vehicle. Cardiac function was studied… 

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