Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.

@article{MurilloRodrguez2006CannabidiolAC,
  title={Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.},
  author={Eric Murillo-Rodr{\'i}guez and Diana Mill{\'a}n-Aldaco and Marcela Palomero-Rivero and Raphael Mechoulam and Ren{\'e} Drucker-Col{\'i}n},
  journal={FEBS letters},
  year={2006},
  volume={580 18},
  pages={4337-45}
}
Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and cannabidiol (CBD) are two major constituents of Cannabis sativa. Delta(9)-THC modulates sleep, but no clear evidence on the role of CBD is available. In order to determine the effects of CBD on sleep, it was administered intracerebroventricular (icv) in a dose of 10 microg/5 microl at the beginning of either the lights-on or the lights-off period. We found that CBD administered during the lights-on period increased wakefulness (W) and decreased… CONTINUE READING

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