Cannabidiol, a Major Phytocannabinoid, As a Potent Atypical Inhibitor for CYP2D6

@article{Yamaori2011CannabidiolAM,
  title={Cannabidiol, a Major Phytocannabinoid, As a Potent Atypical Inhibitor for CYP2D6},
  author={S. Yamaori and Yasuka Okamoto and I. Yamamoto and K. Watanabe},
  journal={Drug Metabolism and Disposition},
  year={2011},
  volume={39},
  pages={2049 - 2056}
}
Δ9-Tetrahydrocannabinol, cannabidiol (CBD), and cannabinol are the three major cannabinoids contained in marijuana, which are devoid of nitrogen atoms in their structures. In this study, we investigated the inhibitory effects of the major phytocannabinoids on the catalytic activity of human CYP2D6. These major cannabinoids inhibited the 3-[2-(N,N-diethyl-N-methylammonium)ethyl]-7-methoxy-4-methylcoumarin (AMMC) and dextromethorphan O-demethylase activities of recombinant CYP2D6 and pooled human… Expand
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