Canine renal receptors for parathyroid hormone. Down-regulation in vivo by exogenous parathyroid hormone.

@article{Mahoney1983CanineRR,
  title={Canine renal receptors for parathyroid hormone. Down-regulation in vivo by exogenous parathyroid hormone.},
  author={C. A. Mahoney and R. Nissenson},
  journal={The Journal of clinical investigation},
  year={1983},
  volume={72 2},
  pages={
          411-21
        }
}
  • C. A. Mahoney, R. Nissenson
  • Published 1983
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • Chronic elevation of circulating parathyroid hormone (PTH) is associated with decreased target cell responsiveness to PTH. To study the subcellular mechanism of this phenomenon we evaluated PTH receptors and adenylate cyclase activity in renal cortical membranes prepared before and after infusion of bovine parathyroid gland extract (PTE) into thyroparathyroidectomized dogs. PTE infusion resulted in a 53% decrease in the number of high-affinity receptors (P less than 0.01) associated with a 66… CONTINUE READING
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