Canine prostate carcinoma: epidemiological evidence of an increased risk in castrated dogs

  title={Canine prostate carcinoma: epidemiological evidence of an increased risk in castrated dogs},
  author={E. Teske and Elaine C Naan and Evert van Dijk and Evert van Garderen and Jack A Schalken},
  journal={Molecular and Cellular Endocrinology},

Canine Prostate Carcinoma: Four Clinical Cases in Sexually Intact and Neutered Dogs

Three cases of prostatic carcinoma in intact sexually dogs and one in a neutered dog are reported, which are the only large mammals other than humans with a significant incidence of spontaneous prostate cancer in dogs.

Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and castration time.

The results show that most canine prostatic carcinomas are of ductal/urothelial, androgen-independent origin, consistent with the epidemiological findings, showing increased risk in castrated dogs.

RETRACTED ARTICLE: Diagnostic investigations of canine prostatitis incidence together with benign prostate hyperplasia, prostate malignancies, and biochemical recurrence in high-risk prostate cancer as a model for human study

Chronic prostatic inflammation could be a central mechanism in BPH progression, but the pathological features of tissue inflammation were different between BPH and prostate cancer (PCa).

Outcome and prognostic factors in medically treated canine prostatic carcinomas: A multi-institutional study.

It is suggested that a combination of NSAIDs and chemotherapy may improve outcomes in canine PC, including time to progression and median survival time.

Total prostatectomy as a treatment for prostatic carcinoma in 25 dogs

Total prostatectomy, combined with adjunct therapies, prolongs survival and lowers complication rates compared to previous reports of dogs with prostatic carcinoma.

Prostatic Neoplasia in the Intact and Castrated Dog: How Dangerous is Castration?

It is concluded that elective gonadectomy of adult male dogs under six years of age cannot be excluded from the veterinary practice due to concern of causing CPN until clear and strong evidence is available.

Prostate cancer in dogs: comparative and clinical aspects.

Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component

It is confirmed that canine PC is characterized by absent or weak expression of basal cell and urothelial markers, and NSE expression, potentially indicating neuroendocrine differentiation, is reported for the first time in canine PCa.



The influence of castration on the development of prostatic carcinoma in the dog. 43 cases (1978-1985).

In this study, castration at any age showed no sparing effect on the risk of development of PC in the dog, and work in humans suggests that the adrenal and pituitary glands play a significant role in the disease.

Prostatic disorders in the dog.

High grade prostatic intraepithelial neoplasia in military working dogs with and without prostate cancer

The prevalence of high grade prostatic intraepithelial neoplasia is determined in prostates of aged military working dogs with and without prostatic adenocarcinoma.

Age-related Changes in the Prostate and Testes of the Beagle Dog

The findings indicate that the progression of benign prostatic hyperplasia occurs throughout the entire life span of the dog; an association with changes in the testes was not identified.

Evaluation of serum and seminal plasma markers in the diagnosis of canine prostatic disorders.

Results show that proteins of prostatic origin appear in the serum of dogs as a result of prostatics pathology, especially BPH, and prostatic adenocarcinoma does not appear to be associated with significant increases in CPSE or AP activities, possibly because of down-regulation of these enzymes by prostatic carcinoma cells.

Role of canine basal cells in prostatic post natal development, induction of hyperplasia, sex hormone‐stimulated growth; and the ductal origin of carcinoma

Investigation of basal cells in canine prostatic development, the evolution of hyperplasia and carcinoma, and the effects of sex hormones on these cells found them to be key participants in normal and abnormal growth of the human gland.

Comparative pathology of benign prostatic hyperplasia and prostate cancer.

The currently available models for the study of benign, and malignant prostate disease are reviewed and the strengths and weaknesses each for preclinical investigations are assessed.

High-grade prostatic intraepithelial neoplasia

High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely preinvasive stage of adenocarcinoma, almost two decades after its first formal description. PIN has a high

Results of conservative management of clinically localized prostate cancer.

The strategy of initial conservative management and delayed hormone therapy is a reasonable choice for some men with grade 1 or 2 clinically localized prostate cancer, particularly for those who have an average life expectancy of 10 years or less.