Canine prostate carcinoma: epidemiological evidence of an increased risk in castrated dogs

@article{Teske2002CaninePC,
  title={Canine prostate carcinoma: epidemiological evidence of an increased risk in castrated dogs},
  author={E. Teske and Elaine C Naan and Evert van Dijk and Evert van Garderen and Jack A Schalken},
  journal={Molecular and Cellular Endocrinology},
  year={2002},
  volume={197},
  pages={251-255}
}

Canine Prostate Carcinoma: Four Clinical Cases in Sexually Intact and Neutered Dogs

TLDR
Three cases of prostatic carcinoma in intact sexually dogs and one in a neutered dog are reported, which are the only large mammals other than humans with a significant incidence of spontaneous prostate cancer in dogs.

Immunohistochemical characterization of canine prostatic carcinoma and correlation with castration status and castration time.

TLDR
The results show that most canine prostatic carcinomas are of ductal/urothelial, androgen-independent origin, consistent with the epidemiological findings, showing increased risk in castrated dogs.

RETRACTED ARTICLE: Diagnostic investigations of canine prostatitis incidence together with benign prostate hyperplasia, prostate malignancies, and biochemical recurrence in high-risk prostate cancer as a model for human study

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Chronic prostatic inflammation could be a central mechanism in BPH progression, but the pathological features of tissue inflammation were different between BPH and prostate cancer (PCa).

Outcome and prognostic factors in medically treated canine prostatic carcinomas: A multi-institutional study.

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It is suggested that a combination of NSAIDs and chemotherapy may improve outcomes in canine PC, including time to progression and median survival time.

Total prostatectomy as a treatment for prostatic carcinoma in 25 dogs

TLDR
Total prostatectomy, combined with adjunct therapies, prolongs survival and lowers complication rates compared to previous reports of dogs with prostatic carcinoma.

Prostatic Neoplasia in the Intact and Castrated Dog: How Dangerous is Castration?

TLDR
It is concluded that elective gonadectomy of adult male dogs under six years of age cannot be excluded from the veterinary practice due to concern of causing CPN until clear and strong evidence is available.

Prostate cancer in dogs: comparative and clinical aspects.

Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component

TLDR
It is confirmed that canine PC is characterized by absent or weak expression of basal cell and urothelial markers, and NSE expression, potentially indicating neuroendocrine differentiation, is reported for the first time in canine PCa.
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