Canine parvovirus infection potentiates canine distemper encephalitis attributable to modified live-virus vaccine.

@article{Krakowka1982CaninePI,
  title={Canine parvovirus infection potentiates canine distemper encephalitis attributable to modified live-virus vaccine.},
  author={Steven G. Krakowka and Richard g. Olsen and Michael K Axthelm and John B. Rice and Katherine Winters},
  journal={Journal of the American Veterinary Medical Association},
  year={1982},
  volume={180 2},
  pages={137-9}
}
Twelve gnotobiotic dogs from 2 litters were allotted to 3 groups. Group A dogs received a modified-live polyvalent (canine distemper, adenovirus type 2, and parainfluenza virus and Leptospira -canicola-icterohemorrhagiae bacterin) vaccine 3 days prior to oral inoculation with canine parvovirus (CPV). Group B dogs received CPV alone. Group C dogs received 1 dose of vaccine only. In none of the 9 CPV-inoculated dogs did clinical signs of CPV infection develop, although high serum antibody titers… CONTINUE READING