Canine parvovirus NS1 induced apoptosis involves mitochondria, accumulation of reactive oxygen species and activation of caspases.

@article{Gupta2016CaninePN,
  title={Canine parvovirus NS1 induced apoptosis involves mitochondria, accumulation of reactive oxygen species and activation of caspases.},
  author={Shishir Kumar Gupta and Aditya Prasad Sahoo and Nighil Rosh and Ravi Kumar Gandham and Lovleen Saxena and Arvind K. Singh and Dureja Harish and Ashok Tiwari},
  journal={Virus research},
  year={2016},
  volume={213},
  pages={46-61}
}
The non-structural protein (NS1) of parvoviruses plays an important role in viral replication and is thought to be responsible for inducing cell death. However, the detailed mechanism and the pathways involved in canine parvovirus type 2 NS1 (CPV2.NS1) induced apoptosis are not yet known. In the present study, we report that expression of CPV2.NS1 in HeLa cells arrests cells in G1 phase of the cell cycle and the apoptosis is mitochondria mediated as indicated by mitochondrial depolarization… CONTINUE READING
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