Canine neutrophil activation by cardiac lymph obtained during reperfusion of ischemic myocardium.

@article{Dreyer1989CanineNA,
  title={Canine neutrophil activation by cardiac lymph obtained during reperfusion of ischemic myocardium.},
  author={William J. Dreyer and Clifton Smith and Lloyd H. Michael and Roger D. Rossen and Bonnie J Hughes and Mark L. Entman and Donald C. Anderson},
  journal={Circulation research},
  year={1989},
  volume={65 6},
  pages={1751-62}
}
Cardiac lymph from a canine model of myocardial ischemia and reperfusion was examined for evidence of chemotactic activity. Lymph was continuously collected from awake animals before and during a 60-minute coronary artery occlusion and up to 6 hours after the initiation of reperfusion. It was assessed for the ability to activate the following proinflammatory functions in neutrophils isolated from the blood of healthy dogs: 1) morphological changes characteristic of chemotactic stimulation… CONTINUE READING