Canine liver transplantation under Nva2-cyclosporine versus cyclosporine.

  title={Canine liver transplantation under Nva2-cyclosporine versus cyclosporine.},
  author={Satoru Todo and Kenneth A Porter and Igal Kam and Sharon Lynch and Raman Venkataramanan and Andre Dewolf and Thomas E. Starzl},
  volume={41 3},
The immunosuppressive qualities and other features of a new cyclosporine (CsA) analogue, Nva2-cyclosporine (Nva2-CsA) were examined using canine orthotopic liver allografts. The mean survival time was 11.8 +/- 9.6 (SD) days in dogs without treatment, 60.8 +/- 4.4 days with Nva2-CsA and 65.1 +/- 33.0 days with CsA. Functional abnormalities indicating toxic side effects were not noted either with Nva2-CsA or with CsA. Using the same oral dose, the rate of blood level rise and the amount of the… CONTINUE READING